Norbert Nass^1,2,#, Mohamad-Kamal Yaakoub^1,#, Alexandra-Victorita Simion³, Hartmut Kroll⁴, Sabine Westphal³, Judith Pannier¹, Gerhard Behre^1,*

Oncology Research, Vol.33, No.10, pp. 2923-2935, 2025, DOI:10.32604/or.2025.067561 - 26 September 2025

Abstract Background: Patients with hemato-oncological malignancies may respond insufficiently to vaccination, especially in terms of antibody titer. The antibody response depends on the type of malignancy as well as the type and timing of treatment. We intended to evaluate this using real-world data from patients of our regional hospital. This study also considers the role of immune status, including T-cell activation markers, in predicting vaccination success. Methods: Seventeen patients of our hospital having a hematological malignancy were included in this study, including myeloma, lymphoma, as well as acute myeloid leukemia (AML) and chronic lymphoid leukemia (CLL).… More >

Mukul Mishra¹, Deeba Khan², Sehbanul Islam^1,*

BIOCELL, Vol.49, No.1, pp. 127-147, 2025, DOI:10.32604/biocell.2025.058038 - 24 January 2025

Abstract The COVID-19 pandemic, caused by the newly emerged coronavirus SARS-CoV-2, has resulted in unprecedented global health challenges, including millions of infections and deaths. While the direct effects of the virus are critical, the interplay between SARS-CoV-2 and cellular host factors significantly impacts the replication cycle of the virus and the clinical severity of COVID-19. This review provides a comprehensive analysis of host-pathogen interactions, focusing on the functional roles and regulatory mechanisms of SARS-CoV-2 viral proteins. We systematically review the literature to detail how SARS-CoV-2 engages with host cellular machinery, with a specific emphasis on their More >

PRIYADHARSHINI THANJAVUR SRIRAMAMOORTHI^1,2, GAYATHRI GOPAL^1,2, SHIBI MURALIDAR^1,2, SAI RAMANAN ESWARAN^1,2, DANUSH NARAYAN PANNEERSELVAM^1,2, BHUVANESWARAN MEIYANATHAN^1,2, SRICHANDRASEKAR THUTHIKKADU INDHUPRAKASH^1,2, SENTHIL VISAGA AMBI^1,2,*

BIOCELL, Vol.47, No.11, pp. 2335-2350, 2023, DOI:10.32604/biocell.2023.029379 - 27 November 2023

Abstract The novel coronavirus pneumonia (COVID-19) is spreading worldwide and threatening people greatly. The routes by which SARS-CoV-2 causes lung injury have grown to be a major concern in the scientific community since patients with new Coronavirus, severe acute respiratory syndrome coronavirus (SARS-CoV-2) have a high likelihood of developing acute respiratory distress syndrome (ARDS) in severe cases. The mortality rate of COVID-19 has increased over the period due to rapid spread, and it becomes crucial to understand the disease epidemiology, pathogenic mechanisms, and suitable treatment strategies. ARDS is a respiratory disorder and is one of the… More > Graphic Abstract

VIBHAV VARSHNEY^1,*, PRASHANT SINGH KUSHWAH², NEETU AGRAWAL¹, AHSAS GOYAL^1,*, GOVIND SINGH²

BIOCELL, Vol.47, No.10, pp. 2141-2149, 2023, DOI:10.32604/biocell.2023.030853 - 08 November 2023

Abstract The persistent global pandemic, COVID-19, stems from the pathogenic influence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), yielding an unprecedented worldwide crisis. With reference to a WHO report, the count of COVID-19 cases had exceeded 754 million by February 03, 2023. Intriguingly, emerging research has spotlighted the intricate interplay of gut microbiota and mitochondrial entities, acting as potent immunomodulatory factors at the cellular and molecular levels. This interconnection operates through a series of dynamic mechanisms. SARS-CoV-2 infection perturbs the delicate equilibrium of gut microbiota, leading to dysbiosis—a signature biomarker. This imbalance is intrinsically linked More >

AMGAD M. RABIE^*

BIOCELL, Vol.47, No.10, pp. 2133-2139, 2023, DOI:10.32604/biocell.2023.030057 - 08 November 2023

Abstract Despite the global decline in the severity of the coronavirus disease 2019 (COVID-19) cases, the disease still represents a major concern to the relevant scientific and medical communities. The primary concern of drug scientists, virologists, and other concerned specialists in this respect is to find ready-to-use suitable and potent anticoronaviral therapies that are broadly effective against the different species/strains of the coronaviruses in general, not only against the current and previous coronaviruses (e.g., the recently-appeared severe acute respiratory syndrome coronavirus 2 “SARS-CoV-2”), i.e., effective antiviral agents for treatment and/or prophylaxis of any coronaviral infections, including More > Graphic Abstract

MOHAMAD ZULKEFLEE SABRI¹, JOANNA BOJARSKA², FAI-CHU WONG^3,4, TSUN-THAI CHAI^3,4,*

BIOCELL, Vol.47, No.8, pp. 1727-1742, 2023, DOI:10.32604/biocell.2023.029272 - 28 August 2023

Abstract Molecular dynamics (MD) simulation is a computational technique that analyzes the movement of a system of particles over a given period. MD can provide detailed information about the fluctuations and conformational changes of biomolecules at the atomic level over time. In recent years, MD has been widely applied to the discovery of peptides and peptide-like molecules that may serve as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inhibitors. This review summarizes recent advances in such explorations, focusing on four protein targets: angiotensin-converting enzyme 2 (ACE2), spike protein (S protein), main protease (M^pro), and papain-like protease (PL^pro).… More > Graphic Abstract

Hassam Tahir¹, Muhammad Shahbaz Khan¹, Fawad Ahmed², Abdullah M. Albarrak³, Sultan Noman Qasem³, Jawad Ahmad^4,*

CMC-Computers, Materials & Continua, Vol.75, No.2, pp. 3517-3535, 2023, DOI:10.32604/cmc.2023.035410 - 31 March 2023

Abstract The COVID-19 outbreak began in December 2019 and was declared a global health emergency by the World Health Organization. The four most dominating variants are Beta, Gamma, Delta, and Omicron. After the administration of vaccine doses, an eminent decline in new cases has been observed. The COVID-19 vaccine induces neutralizing antibodies and T-cells in our bodies. However, strong variants like Delta and Omicron tend to escape these neutralizing antibodies elicited by COVID-19 vaccination. Therefore, it is indispensable to study, analyze and most importantly, predict the response of SARS-CoV-2-derived t-cell epitopes against Covid variants in vaccinated… More >

WEI WANG^1,#, YANRONG PEI^2,#, SHUI-HUA WANG¹, JUAN MANUEL GORRZ³, YU-DONG ZHANG^1,*

BIOCELL, Vol.47, No.2, pp. 373-384, 2023, DOI:10.32604/biocell.2023.025905 - 18 November 2022

Abstract Since 2019, the coronavirus disease-19 (COVID-19) has been spreading rapidly worldwide, posing an unignorable threat to the global economy and human health. It is a disease caused by severe acute respiratory syndrome coronavirus 2, a single-stranded RNA virus of the genus Betacoronavirus. This virus is highly infectious and relies on its angiotensin-converting enzyme 2-receptor to enter cells. With the increase in the number of confirmed COVID-19 diagnoses, the difficulty of diagnosis due to the lack of global healthcare resources becomes increasingly apparent. Deep learning-based computer-aided diagnosis models with high generalisability can effectively alleviate this pressure.… More >

QIANG WANG^#, GUO ZHAO^#, LONGXIANG XIE^#, XUAN LI, XIXI YU, QIONGSHAN LI, BAOPING ZHENG, ZULIPINUER WUSIMAN, XIANGQIAN GUO^*

BIOCELL, Vol.47, No.2, pp. 367-371, 2023, DOI:10.32604/biocell.2023.025310 - 18 November 2022

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen of the ongoing coronavirus disease 2019 (COVID-19) global pandemic. Here, by centralizing published cell-based experiments, clinical trials, and virtual drug screening data from the NCBI PubMed database, we developed a database of SARS-CoV-2 inhibitors for COVID-19, dbSCI, which includes 234 SARS-CoV-2 inhibitors collected from publications based on cell-based experiments, 81 drugs of COVID-19 in clinical trials and 1305 potential SARS-CoV-2 inhibitors from bioinformatics analyses. dbSCI provides four major functions: (1) search the drug target or its inhibitor for SARS-CoV-2, (2) browse target/inhibitor information collected from More >

Tahir Khan¹, Rahman Ullah¹, Thabet Abdeljawad^2,3,*, Manar A. Alqudah⁴, Faizullah Faiz⁵

CMES-Computer Modeling in Engineering & Sciences, Vol.135, No.2, pp. 1295-1313, 2023, DOI:10.32604/cmes.2022.022177 - 27 October 2022

Abstract We propose a theoretical study investigating the spread of the novel coronavirus (COVID-19) reported in Wuhan City of China in 2019. We develop a mathematical model based on the novel corona virus's characteristics and then use fractional calculus to fractionalize it. Various fractional order epidemic models have been formulated and analyzed using a number of iterative and numerical approaches while the complications arise due to singular kernel. We use the well-known Caputo-Fabrizio operator for the purposes of fictionalization because this operator is based on the non-singular kernel. Moreover, to analyze the existence and uniqueness, we will More >