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  • Open Access


    Molecular dynamics-driven exploration of peptides targeting SARS-CoV-2, with special attention on ACE2, S protein, Mpro, and PLpro: A review


    BIOCELL, Vol.47, No.8, pp. 1727-1742, 2023, DOI:10.32604/biocell.2023.029272

    Abstract Molecular dynamics (MD) simulation is a computational technique that analyzes the movement of a system of particles over a given period. MD can provide detailed information about the fluctuations and conformational changes of biomolecules at the atomic level over time. In recent years, MD has been widely applied to the discovery of peptides and peptide-like molecules that may serve as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inhibitors. This review summarizes recent advances in such explorations, focusing on four protein targets: angiotensin-converting enzyme 2 (ACE2), spike protein (S protein), main protease (Mpro), and papain-like protease (PLpro). These four proteins are… More > Graphic Abstract

    Molecular dynamics-driven exploration of peptides targeting SARS-CoV-2, with special attention on ACE2, S protein, M<sup>pro</sup>, and PL<sup>pro</sup>: A review

  • Open Access


    Effect of Online Social Networking on Emotional Status and Its Interaction with Offline Reality during the Early Stage of the COVID-19 Pandemic in China

    Xiaolin Lu1,*, Xiaolei Miao2

    International Journal of Mental Health Promotion, Vol.25, No.9, pp. 1041-1052, 2023, DOI:10.32604/ijmhp.2023.030232

    Abstract Background: During the early stages of the COVID-19 pandemic in China, social interactions shifted to online spaces due to lock-downs and social distancing measures. As a result, the impact of online social networking on users’ emotional status has become stronger than ever. This study examines the association between online social networking and Internet users’ emotional status and how offline reality affects this relationship. Methods: The study utilizes cross-sectional online survey data (n = 3004) and Baidu Migration big data from the first 3 months of the pandemic. Two dimensions of online networking are measured: social support and information sources. Results:More > Graphic Abstract

    Effect of Online Social Networking on Emotional Status and Its Interaction with Offline Reality during the Early Stage of the COVID-19 Pandemic in China

  • Open Access


    Dynamical Analysis of the Stochastic COVID-19 Model Using Piecewise Differential Equation Technique

    Yu-Ming Chu1, Sobia Sultana2, Saima Rashid3,*, Mohammed Shaaf Alharthi4

    CMES-Computer Modeling in Engineering & Sciences, Vol.137, No.3, pp. 2427-2464, 2023, DOI:10.32604/cmes.2023.028771

    Abstract Various data sets showing the prevalence of numerous viral diseases have demonstrated that the transmission is not truly homogeneous. Two examples are the spread of Spanish flu and COVID-19. The aim of this research is to develop a comprehensive nonlinear stochastic model having six cohorts relying on ordinary differential equations via piecewise fractional differential operators. Firstly, the strength number of the deterministic case is carried out. Then, for the stochastic model, we show that there is a critical number that can predict virus persistence and infection eradication. Because of the peculiarity of this notion, an interesting way… More >

  • Open Access


    A Novel Edge-Assisted IoT-ML-Based Smart Healthcare Framework for COVID-19

    Mahmood Hussain Mir1,*, Sanjay Jamwal1, Ummer Iqbal2, Abolfazl Mehbodniya3, Julian Webber3, Umar Hafiz Khan4

    CMES-Computer Modeling in Engineering & Sciences, Vol.137, No.3, pp. 2529-2565, 2023, DOI:10.32604/cmes.2023.027173

    Abstract The lack of modern technology in healthcare has led to the death of thousands of lives worldwide due to COVID- 19 since its outbreak. The Internet of Things (IoT) along with other technologies like Machine Learning can revolutionize the traditional healthcare system. Instead of reactive healthcare systems, IoT technology combined with machine learning and edge computing can deliver proactive and preventive healthcare services. In this study, a novel healthcare edge-assisted framework has been proposed to detect and prognosticate the COVID-19 suspects in the initial phases to stop the transmission of coronavirus infection. The proposed framework is based on edge computing… More >

  • Open Access


    A Restricted SIR Model with Vaccination Effect for the Epidemic Outbreaks Concerning COVID-19

    Ibtehal Alazman1, Kholoud Saad Albalawi1, Pranay Goswami2,*, Kuldeep Malik2

    CMES-Computer Modeling in Engineering & Sciences, Vol.137, No.3, pp. 2409-2425, 2023, DOI:10.32604/cmes.2023.028674

    Abstract This paper presents a restricted SIR mathematical model to analyze the evolution of a contagious infectious disease outbreak (COVID-19) using available data. The new model focuses on two main concepts: first, it can present multiple waves of the disease, and second, it analyzes how far an infection can be eradicated with the help of vaccination. The stability analysis of the equilibrium points for the suggested model is initially investigated by identifying the matching equilibrium points and examining their stability. The basic reproduction number is calculated, and the positivity of the solutions is established. Numerical simulations are performed to determine if… More >

  • Open Access


    Systematic Survey on Big Data Analytics and Artificial Intelligence for COVID-19 Containment

    Saeed M. Alshahrani1, Jameel Almalki2, Waleed Alshehri2, Rashid Mehmood3, Marwan Albahar2, Najlaa Jannah2, Nayyar Ahmed Khan1,*

    Computer Systems Science and Engineering, Vol.47, No.2, pp. 1793-1817, 2023, DOI:10.32604/csse.2023.039648

    Abstract Artificial Intelligence (AI) has gained popularity for the containment of COVID-19 pandemic applications. Several AI techniques provide efficient mechanisms for handling pandemic situations. AI methods, protocols, data sets, and various validation mechanisms empower the users towards proper decision-making and procedures to handle the situation. Despite so many tools, there still exist conditions in which AI must go a long way. To increase the adaptability and potential of these techniques, a combination of AI and Bigdata is currently gaining popularity. This paper surveys and analyzes the methods within the various computational paradigms used by different researchers and national governments, such as… More >

  • Open Access


    Robust Deep Learning Model for Black Fungus Detection Based on Gabor Filter and Transfer Learning

    Esraa Hassan1, Fatma M. Talaat1, Samah Adel2, Samir Abdelrazek3, Ahsan Aziz4, Yunyoung Nam4,*, Nora El-Rashidy1

    Computer Systems Science and Engineering, Vol.47, No.2, pp. 1507-1525, 2023, DOI:10.32604/csse.2023.037493

    Abstract Black fungus is a rare and dangerous mycology that usually affects the brain and lungs and could be life-threatening in diabetic cases. Recently, some COVID-19 survivors, especially those with co-morbid diseases, have been susceptible to black fungus. Therefore, recovered COVID-19 patients should seek medical support when they notice mucormycosis symptoms. This paper proposes a novel ensemble deep-learning model that includes three pre-trained models: reset (50), VGG (19), and Inception. Our approach is medically intuitive and efficient compared to the traditional deep learning models. An image dataset was aggregated from various resources and divided into two classes: a black fungus class… More >

  • Open Access


    On Fractional Differential Inclusion for an Epidemic Model via L-Fuzzy Fixed Point Results

    Maha Noorwali1, Mohammed Shehu Shagari2,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.137, No.2, pp. 1937-1956, 2023, DOI:10.32604/cmes.2023.028239

    Abstract The real world is filled with uncertainty, vagueness, and imprecision. The concepts we meet in everyday life are vague rather than precise. In real-world situations, if a model requires that conclusions drawn from it have some bearings on reality, then two major problems immediately arise, viz. real situations are not usually crisp and deterministic; complete descriptions of real systems often require more comprehensive data than human beings could recognize simultaneously, process and understand. Conventional mathematical tools which require all inferences to be exact, are not always efficient to handle imprecisions in a wide variety of practical situations. Following the latter… More >

  • Open Access


    Performance Comparison of Deep and Machine Learning Approaches Toward COVID-19 Detection

    Amani Yahyaoui1, Jawad Rasheed2,*, Shtwai Alsubai3, Raed M. Shubair4, Abdullah Alqahtani5, Buket Isler6, Rana Zeeshan Haider7

    Intelligent Automation & Soft Computing, Vol.37, No.2, pp. 2247-2261, 2023, DOI:10.32604/iasc.2023.036840

    Abstract The coronavirus (COVID-19) is a disease declared a global pandemic that threatens the whole world. Since then, research has accelerated and varied to find practical solutions for the early detection and correct identification of this disease. Several researchers have focused on using the potential of Artificial Intelligence (AI) techniques in disease diagnosis to diagnose and detect the coronavirus. This paper developed deep learning (DL) and machine learning (ML) -based models using laboratory findings to diagnose COVID-19. Six different methods are used in this study: K-nearest neighbor (KNN), Decision Tree (DT) and Naive Bayes (NB) as a machine learning method, and… More >

  • Open Access


    Cost Efficient Automated Fog Spraying Machine: A Covid-19 Hand Sanitization Solution

    M. Atikur Rahman*, Amranur Rahman, Arman Hossain, Arifur Rahman Bhuiyan

    Journal of New Media, Vol.5, No.1, pp. 33-43, 2023, DOI:10.32604/jnm.2023.038676

    Abstract As a result of the introduction of new infectious illnesses, key infection prevention measures were implemented. Now, a new coronavirus (SARS-CoV-2) epidemic has expanded swiftly, causing the coronavirus illness 2019 (COVID-19). Many microorganisms spread illness via hospital surfaces due to environmental pollution. This virus has been associated to close contact between persons in tight situations such as houses, hospitals, assisted living, and residential institutions. Aside from health care settings, public buildings, faith-based community centers, marketplaces, transportation, and corporate environments are prone to COVID-19 transmission. Physical contact to the sanitizer device may cause for spread Covid virus. That’s why we have… More >

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