Xiaobing Li^1,2, Yongsheng Liu¹, Limin Wei¹, Li Rao¹, Jingxin Mao^1,*, Xuemei Li^3,*

BIOCELL, Vol.49, No.5, pp. 813-832, 2025, DOI:10.32604/biocell.2025.062124 - 27 May 2025

Abstract Yeast-based models have become a powerful platform in pharmaceutical research, offering significant potential for producing complex drugs, vaccines, and therapeutic agents. While many current drugs were discovered before fully understanding their molecular mechanisms, yeast systems now provide valuable insights for drug discovery and personalized medicine. Recent advancements in genetic engineering, metabolic engineering, and synthetic biology have improved the efficiency and scalability of yeast-based production systems, enabling more sustainable and cost-effective manufacturing processes. This paper reviews the latest developments in yeast-based technologies, focusing on their use as model organisms to study disease mechanisms, identify drug targets,… More >

Yuling Luo^1,2, Xiaoguang Lin^1,2, Junxiu Liu^1,2,*, Qiang Fu^1,2, Sheng Qin^1,2, Zhen Min^1,2, Tinghua Hu^1,2

CMC-Computers, Materials & Continua, Vol.83, No.3, pp. 5323-5343, 2025, DOI:10.32604/cmc.2025.063860 - 19 May 2025

Abstract The majors accredited by the Engineering Education Accreditation (EEA) reflect the accreditation agency’s recognition of the school’s engineering programs. Excellent accreditation management holds significant importance for the advancement of engineering education programs. However, the traditional engineering education system framework suffers from the opacity of raw education data and the difficulty for accreditation bodies to forensically examine the self-assessment reports. To solve these issues, an EEA framework based on Hyperledger Fabric blockchain technology is proposed in this work. Firstly, all relevant stakeholders and information interactions occur within the blockchain network, ensuring the authenticity of educational data More >

Qingqing Song^1,*, Shaoliang Xia¹, Zhen Wu²

CMC-Computers, Materials & Continua, Vol.83, No.2, pp. 2619-2642, 2025, DOI:10.32604/cmc.2025.062526 - 16 April 2025

Abstract Load time series analysis is critical for resource management and optimization decisions, especially automated analysis techniques. Existing research has insufficiently interpreted the overall characteristics of samples, leading to significant differences in load level detection conclusions for samples with different characteristics (trend, seasonality, cyclicality). Achieving automated, feature-adaptive, and quantifiable analysis methods remains a challenge. This paper proposes a Threshold Recognition-based Load Level Detection Algorithm (TRLLD), which effectively identifies different load level regions in samples of arbitrary size and distribution type based on sample characteristics. By utilizing distribution density uniformity, the algorithm classifies data points and ultimately… More >

Yue Liu¹, Qinglang Guo², Chunyao Yang¹, Yong Liao^1,*

CMC-Computers, Materials & Continua, Vol.83, No.2, pp. 2555-2572, 2025, DOI:10.32604/cmc.2025.060318 - 16 April 2025

Abstract Processing police incident data in public security involves complex natural language processing (NLP) tasks, including information extraction. This data contains extensive entity information—such as people, locations, and events—while also involving reasoning tasks like personnel classification, relationship judgment, and implicit inference. Moreover, utilizing models for extracting information from police incident data poses a significant challenge—data scarcity, which limits the effectiveness of traditional rule-based and machine-learning methods. To address these, we propose TIPS. In collaboration with public security experts, we used de-identified police incident data to create templates that enable large language models (LLMs) to populate data More >

Nour Elhouda Chalabi¹, Abdelouahab Attia², Abdulaziz S. Almazyad³, Ali Wagdy Mohamed^4,5, Frank Werner⁶, Pradeep Jangir⁷, Mohammad Shokouhifar^8,9,*

CMES-Computer Modeling in Engineering & Sciences, Vol.143, No.1, pp. 967-1008, 2025, DOI:10.32604/cmes.2025.062332 - 11 April 2025

Abstract Multi-objective optimization is critical for problem-solving in engineering, economics, and AI. This study introduces the Multi-Objective Chef-Based Optimization Algorithm (MOCBOA), an upgraded version of the Chef-Based Optimization Algorithm (CBOA) that addresses distinct objectives. Our approach is unique in systematically examining four dominance relations—Pareto, Epsilon, Cone-epsilon, and Strengthened dominance—to evaluate their influence on sustaining solution variety and driving convergence toward the Pareto front. Our comparison investigation, which was conducted on fifty test problems from the CEC 2021 benchmark and applied to areas such as chemical engineering, mechanical design, and power systems, reveals that the dominance approach More >

Ruhul Amin¹, Md. Jamil Khan¹, Tonway Deb Nath¹, Md. Shamim Reza², Jungpil Shin^3,*

CMC-Computers, Materials & Continua, Vol.82, No.3, pp. 3907-3919, 2025, DOI:10.32604/cmc.2025.061645 - 06 March 2025

Abstract Heart disease includes a multiplicity of medical conditions that affect the structure, blood vessels, and general operation of the heart. Numerous researchers have made progress in correcting and predicting early heart disease, but more remains to be accomplished. The diagnostic accuracy of many current studies is inadequate due to the attempt to predict patients with heart disease using traditional approaches. By using data fusion from several regions of the country, we intend to increase the accuracy of heart disease prediction. A statistical approach that promotes insights triggered by feature interactions to reveal the intricate pattern… More >

Bin Sun¹, Yinuo Wang¹, Tao Shen^1,*, Lu Zhang¹, Renkang Geng²

CMC-Computers, Materials & Continua, Vol.82, No.3, pp. 4219-4236, 2025, DOI:10.32604/cmc.2025.060567 - 06 March 2025

Abstract Traffic datasets exhibit complex spatiotemporal characteristics, including significant fluctuations in traffic volume and intricate periodical patterns, which pose substantial challenges for the accurate forecasting and effective management of traffic conditions. Traditional forecasting models often struggle to adequately capture these complexities, leading to suboptimal predictive performance. While neural networks excel at modeling intricate and nonlinear data structures, they are also highly susceptible to overfitting, resulting in inefficient use of computational resources and decreased model generalization. This paper introduces a novel heuristic feature extraction method that synergistically combines the strengths of non-neural network algorithms with neural networks… More >

Shoaib Hassan^1,*, Qianmu Li^1,*, Muhammad Zubair², Rakan A. Alsowail³, Muhammad Umair²

CMC-Computers, Materials & Continua, Vol.82, No.3, pp. 4041-4067, 2025, DOI:10.32604/cmc.2025.059832 - 06 March 2025

Abstract As the trend to use the latest machine learning models to automate requirements engineering processes continues, security requirements classification is tuning into the most researched field in the software engineering community. Previous literature studies have proposed numerous models for the classification of security requirements. However, adopting those models is constrained due to the lack of essential datasets permitting the repetition and generalization of studies employing more advanced machine learning algorithms. Moreover, most of the researchers focus only on the classification of requirements with security keywords. They did not consider other nonfunctional requirements (NFR) directly or… More >

Mohamed A.G. Hazber^1,*, Ebrahim Mohammed Senan^2,3, Hezam Saud Alrashidi¹

CMES-Computer Modeling in Engineering & Sciences, Vol.142, No.3, pp. 3229-3254, 2025, DOI:10.32604/cmes.2025.062302 - 03 March 2025

Abstract Hepatitis is an infection that affects the liver through contaminated foods or blood transfusions, and it has many types, from normal to serious. Hepatitis is diagnosed through many blood tests and factors; Artificial Intelligence (AI) techniques have played an important role in early diagnosis and help physicians make decisions. This study evaluated the performance of Machine Learning (ML) algorithms on the hepatitis data set. The dataset contains missing values that have been processed and outliers removed. The dataset was counterbalanced by the Synthetic Minority Over-sampling Technique (SMOTE). The features of the data set were processed… More >

Mohammed A. El-Shorbagy¹, Anas Bouaouda^2,*, Laith Abualigah^3,4, Fatma A. Hashim^5,6

CMES-Computer Modeling in Engineering & Sciences, Vol.142, No.3, pp. 2339-2404, 2025, DOI:10.32604/cmes.2025.061028 - 03 March 2025

Abstract With the rapid advancements in technology and science, optimization theory and algorithms have become increasingly important. A wide range of real-world problems is classified as optimization challenges, and meta-heuristic algorithms have shown remarkable effectiveness in solving these challenges across diverse domains, such as machine learning, process control, and engineering design, showcasing their capability to address complex optimization problems. The Stochastic Fractal Search (SFS) algorithm is one of the most popular meta-heuristic optimization methods inspired by the fractal growth patterns of natural materials. Since its introduction by Hamid Salimi in 2015, SFS has garnered significant attention… More >