Jing Zhang^1,2,3, Xiuqing Qian^1,2, Haixia Zhang^1,2, Zhicheng Liu^1,2,*

CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 301-314, 2018, DOI:10.31614/cmes.2018.04239

Abstract Elevated intraocular pressure appears to have a broader impact on increased resistance to aqueous humor outflow through the conventional aqueous outflow system (AOS). However, there is still no consensus about exact location of the increased outflow resistance of aqueous humor, and the mechanism is not perfect. In addition, it is difficult to accurately obtain hydrodynamic parameters of aqueous humor within the trabecular meshwork outflow pathways based on the current technology. In this paper, a two-way fluid-structure interaction simulation was performed to study the pressure difference and velocity in the superficial trabecular meshwork, juxtacanalicular meshwork (JCM) More >

Jianhang Du^1,2,3, Liang Wang⁴

Molecular & Cellular Biomechanics, Vol.12, No.4, pp. 249-263, 2015, DOI:10.3970/mcb.2015.012.249

Abstract Growing evidences suggest that long-term enhanced external counterpulsation (EECP) treatment can inhibit the initiation of atherosclerotic lesion by improving the hemodynamic environment in aortas. However, whether this kind procedure will intervene the progression of advanced atherosclerotic plaque remains elusive and causes great concern in its clinical application presently. In the current paper, a pilot study combining animal experiment and numerical simulation was conducted to investigate the acute mechanical stress variations during EECP intervention, and then to assess the possible chronic effects. An experimentally induced hypercholesterolemic porcine model was developed and the basic hemodynamic measurement was… More >

Hongjian Wang^*, Jie Zheng^†, LiangWang^‡, Akiko Maehara^§, Chun Yang^II, David Muccigrosso^†, Richard Bachk^II, Jian Zhu^**, Gary S. Mintz^§, Dalin Tang^*,‡,††

Molecular & Cellular Biomechanics, Vol.12, No.2, pp. 107-122, 2015, DOI:10.3970/mcb.2015.012.107

Abstract Computational modeling has been used extensively in cardiovascular and biological research, providing valuable information. However, 3D vulnerable plaque model construction with complex geometrical features and multicomponents is often very time consuming and not practical for clinical implementation. This paper investigated if 2D atherosclerotic plaque models could be used to replace 3D models to perform correlation analysis and achieve similar results. In vivo intravascular ultrasound (IVUS) coronary plaque data were acquired from a patient follow-up study to construct 2D structure-only and 3D FSI models to obtain plaque wall stress (PWS) and strain (PWSn) data. One hundred… More >

Heng Zuo^*, Dalin Tang^*,†,‡, Chun Yang^*,§, Glenn Gaudette^¶, Kristen L. Billiar^¶, Pedro J. del Nidok^II

Molecular & Cellular Biomechanics, Vol.12, No.2, pp. 67-85, 2015, DOI:10.3970/mcb.2015.012.067

Abstract Right ventricular (RV) dysfunction is a common cause of heart failure in patients with congenital heart defects and often leads to impaired functional capacity and premature death. Myocardial tissue regeneration techniques are being developed for the potential that viable myocardium may be regenerated to replace scar tissues in the heart or used as patch material in heart surgery. 3D computational RV/LV/Patch models with fluid-structure interactions (FSI) were constructed based on data from a healthy dog heart to obtain local fluid dynamics and structural stress/strain information and identify optimal conditions under which tissue regeneration techniques could… More >

L.L. Chen¹, H.B. Chen^1,2

CMES-Computer Modeling in Engineering & Sciences, Vol.107, No.3, pp. 249-276, 2015, DOI:10.3970/cmes.2015.107.249

Abstract Engineers have started to develop ways to decrease noise radiation. Structural-acoustic design sensitivity analysis can provide information on how changes in design variable affect the radiated acoustic performance. As such, it is an important step in the structural-acoustic design and in optimization processes. For thin structures immersed in water, a full interaction between the structural domain and the fluid domain needs to be taken into account. In this work, the finite element method is used to model the structure parts and the boundary element method is applied to the exterior acoustic problem. The formula of More >

P. Pasolini^1,2, R. Savino¹, F. Franco¹, S. De Rosa¹

FDMP-Fluid Dynamics & Materials Processing, Vol.11, No.3, pp. 301-324, 2015, DOI:10.3970/fdmp.2015.011.301

Abstract The aim of the present work is to provide a first attempt to set an aero-thermo-elastic methodology for deployable atmospheric re-entry decelerators operating at high Mach number and high dynamic pressure. Because of the severity of re-entry conditions such as high temperatures, high pressures and high velocities, the behavior of their flexible structures is a hard target to assess. In this paper a partitioned Fluid Structure Interaction (FSI) approach based on the integration of different commercial software (STAR-CCM+ and ABAQUS) is presented. In order to validate the specific codes and the overall strategy for structural More >

Zheng-qi Liu^∗, Ying Liu^∗,†, Tian-tian Liu^∗, Qing-shan Yang^‡

Molecular & Cellular Biomechanics, Vol.11, No.2, pp. 129-149, 2014, DOI:10.3970/mcb.2014.011.129

Abstract In this paper, the hemodynamic characteristics of blood flow and stress distribution in a layered and stenotic aorta are investigated. By introducing symmetrical and unsymmetrical stenosis, the influence of stenosis morphology and stenotic ratio on the coupled dynamic responses of aorta is clarified. In the analysis, the in-vivo pulsatile waveforms and fully fluid–structure interaction (FSI) between the layered elastic aorta and the blood are considered. The results show that the fluid domain is abnormal in the stenotic aorta, and the whirlpool forms at the obstructed and downstream unobstructed regions. The maximum wall shear stresses appear… More >

X. X. Cui¹, X. Zhang^1,2, X. Zhou³, Y. Liu¹, F. Zhang¹

CMES-Computer Modeling in Engineering & Sciences, Vol.98, No.6, pp. 565-599, 2014, DOI:10.3970/cmes.2014.098.565

Abstract The material point method (MPM) discretizes the material domain by a set of particles, and has showed advantages over the mesh-based methods for many challenging problems associated with large deformation. However, at the same time, it requires more computational resource and has difficulties to construct high order scheme when simulating the fluid in high explosive (HE) explosion problems. A coupled finite difference material point (CFDMP) method is proposed through a bridge region to combine the advantages of the finite difference method (FDM) and MPM. It solves a 3D HE explosion and its interaction with the… More >

D. Ishihara¹, T. Horie¹

CMES-Computer Modeling in Engineering & Sciences, Vol.101, No.6, pp. 421-440, 2014, DOI:10.3970/cmes.2014.101.421

Abstract In this study, a projection method for the monolithic interaction system of an incompressible fluid and a structure using a new algebraic splitting is proposed. The proposed method splits the monolithic equation system into the equilibrium equations and the pressure Poisson equation (PPE) algebraically using the intermediate velocity in the nonlinear iterations. Since the proposed equilibrium equation satisfies the interface condition, the proposed method is strongly coupled. Moreover, the proposed PPE enforces the incompressibility constraint. Different from previous studies, the proposed algebraic splitting never generates any Schur complement. The proposed method is applied to a More >

N. Mitsume¹, S. Yoshimura¹, K. Murotani¹, T. Yamada¹

CMES-Computer Modeling in Engineering & Sciences, Vol.101, No.4, pp. 229-247, 2014, DOI:10.3970/cmes.2014.101.229

Abstract The MPS-FE method, which adopts the Finite Element (FE) method for structure computation and the Moving Particle Simulation (MPS) method for fluid computation involving free surfaces, was developed to solve fluid-structure interaction problems with free surfaces. The conventional MPS-FE method, in which MPS wall boundary particles and finite elements are overlapped in order to exchange information at a fluid-structure interface, is not versatile and reduces the advantages of the software modularity. In this study, we developed a nonoverlapping approach in which the interface in the fluid computation corresponds to the interface in the structure computation More >