Xueying Huang^*, Chun Yang^†, Chun Yuan^‡, Fei Liu^‡, Gador Canton^‡, Jie Zheng^§, Pamela K. Woodard^§, Gregorio A. Sicard^¶, Dalin Tang^||

Molecular & Cellular Biomechanics, Vol.6, No.2, pp. 121-134, 2009, DOI:10.3970/mcb.2009.006.121

Abstract Image-based computational models for atherosclerotic plaques have been developed to perform mechanical analysis to quantify critical flow and stress/strain conditions related to plaque rupture which often leads directly to heart attack or stroke. An important modeling issue is how to determine zero stress state from in vivo plaque geometries. This paper presents a method to quantify human carotid artery axial and inner circumferential shrinkages by using patient-specific ex vivo and in vivo MRI images. A shrink-stretch process based on patient-specific in vivo plaque morphology and shrinkage data was introduced to shrink the in vivo geometry first to find the zero-stress… More >

Chun Yang^∗,†, Dalin Tang^∗,‡, Shunichi Kobayashi^§, Jie Zheng^¶, Pamela K. Woodard^§, Zhongzhao Teng^*, Richard Bach^||, David N. Ku^∗∗

Molecular & Cellular Biomechanics, Vol.5, No.4, pp. 259-274, 2008, DOI:10.3970/mcb.2008.005.259

Abstract Many acute cardiovascular syndromes such as heart attack and stroke are caused by atherosclerotic plaque ruptures which often happen without warning. MRI-based models with fluid-structure interactions (FSI) have been introduced to perform flow and stress/strain analysis for atherosclerotic plaques and identify possible mechanical and morphological indices for accurate plaque vulnerability assessment. In this paper, cyclic bending was added to 3D FSI coronary plaque models for more accurate mechanical predictions. Curvature variation was prescribed using the data of a human left anterior descending (LAD) coronary artery. Five computational models were constructed based on ex vivo MRI human coronary plaque data to… More >

Abhijit Sinha Roy^*, Lloyd H. Back^†, Rupak K. Banerjee^‡

Molecular & Cellular Biomechanics, Vol.5, No.4, pp. 229-246, 2008, DOI:10.3970/mcb.2008.005.229

Abstract The in vivo and ex vivo compliance of arteries are expected to be closely related and estimated. Fluid-structure interaction analysis can assess the agreement between the two compliances. To evaluate this hypothesis, a pulsatile fluid-structure interaction analysis of blood flow in femoral artery of a dog was conducted using: (1) measured in vivo mean pressure (72.5 mmHg), mean pressure drop (0.59 mmHg), mean velocity (15.1 cm/sec); and (2) ex vivo measurements of non -- linear elastic properties of femoral artery. Additional analyses were conducted for physiological pressures (104.1 and 140.7 mmHg) and blood flow using a characteristic linear pressure --… More >

Dalin Tang^*, Chun Yang^†, Tal Geva^‡,§, Pedro J. del Nido^¶

Molecular & Cellular Biomechanics, Vol.4, No.3, pp. 159-176, 2007, DOI:10.3970/mcb.2007.004.159

Abstract A single-layer isotropic patient-specific right/left ventricle and patch (RV/LV/Patch) combination model with fluid-structure interactions (FSI) was introduced in our previous papers to evaluate and optimize human pulmonary valve replacement/insertion (PVR) surgical procedure and patch design. In this paper, an active anisotropic model with two-layer structure for ventricle wall and tissue fiber orientation was introduced to improve previous isotropic model for more accurate assessment of RV function and potential application in PVR surgery and patch design. A material-stiffening approach was used to model active heart contraction. The computational models were used to conduct ``virtual (computational)'' surgeries and test the hypothesis that… More >

Yang Liu^1,*, Yue Qiao², Tiange Li³

CMES-Computer Modeling in Engineering & Sciences, Vol.120, No.1, pp. 177-201, 2019, DOI:10.32604/cmes.2019.06338

Abstract This paper studies the effect of ice resistance on the icebreaking capacity and speed of an icebreaking vessel. We combine an improved Correct Smoothed Particle Method (CSPM) with a material low-speed collision fracture model to numerically simulate the continuous icebreaking and rolling process of crushed. Using this model, we investigate the icebreaking resistance and immersion resistance during the icebreaking process, taking into account the fluid (water) as the elastic boundary support and the fluid-solid coupling interaction. We compare the icebreaking resistance and broken ice fracture shapes obtained by the numerical calculation with the theoretical analytical results, and thus validate the… More >

Zhaoli Tian^1,2, Yunlong Liu^1,2,*, Shiping Wang¹, A Man Zhang¹, Youwei Kang³

CMES-Computer Modeling in Engineering & Sciences, Vol.118, No.2, pp. 397-423, 2019, DOI:10.31614/cmes.2019.04419

Abstract The low frequency load of an underwater explosion bubble and the generated waves can cause significant rigid motion of a ship that threaten its stability. In order to study the fluid-structure interaction qualitatively, a two-dimensional underwater explosion bubble dynamics model, based on the potential flow theory, is established with a double-vortex model for the doubly connected bubble dynamics simulation, and the bubble shows similar dynamics to that in 3-dimensional domain. A fully nonlinear fluid-structure interaction model is established considering the rigid motion of the floating body using the mode-decomposition method. Convergence test of the model is implemented by simulating the… More >

Jing Zhang^1,2,3, Xiuqing Qian^1,2, Haixia Zhang^1,2, Zhicheng Liu^1,2,*

CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 301-314, 2018, DOI: 10.31614/cmes.2018.04239

Abstract Elevated intraocular pressure appears to have a broader impact on increased resistance to aqueous humor outflow through the conventional aqueous outflow system (AOS). However, there is still no consensus about exact location of the increased outflow resistance of aqueous humor, and the mechanism is not perfect. In addition, it is difficult to accurately obtain hydrodynamic parameters of aqueous humor within the trabecular meshwork outflow pathways based on the current technology. In this paper, a two-way fluid-structure interaction simulation was performed to study the pressure difference and velocity in the superficial trabecular meshwork, juxtacanalicular meshwork (JCM) and Schlemm’s canal in response… More >

L.L. Chen¹, H.B. Chen^1,2

CMES-Computer Modeling in Engineering & Sciences, Vol.107, No.3, pp. 249-276, 2015, DOI:10.3970/cmes.2015.107.249

Abstract Engineers have started to develop ways to decrease noise radiation. Structural-acoustic design sensitivity analysis can provide information on how changes in design variable affect the radiated acoustic performance. As such, it is an important step in the structural-acoustic design and in optimization processes. For thin structures immersed in water, a full interaction between the structural domain and the fluid domain needs to be taken into account. In this work, the finite element method is used to model the structure parts and the boundary element method is applied to the exterior acoustic problem. The formula of the sound pressure sensitivity based… More >

X. X. Cui¹, X. Zhang^1,2, X. Zhou³, Y. Liu¹, F. Zhang¹

CMES-Computer Modeling in Engineering & Sciences, Vol.98, No.6, pp. 565-599, 2014, DOI:10.3970/cmes.2014.098.565

Abstract The material point method (MPM) discretizes the material domain by a set of particles, and has showed advantages over the mesh-based methods for many challenging problems associated with large deformation. However, at the same time, it requires more computational resource and has difficulties to construct high order scheme when simulating the fluid in high explosive (HE) explosion problems. A coupled finite difference material point (CFDMP) method is proposed through a bridge region to combine the advantages of the finite difference method (FDM) and MPM. It solves a 3D HE explosion and its interaction with the surrounding structures by dividing the… More >

D. Ishihara¹, T. Horie¹

CMES-Computer Modeling in Engineering & Sciences, Vol.101, No.6, pp. 421-440, 2014, DOI:10.3970/cmes.2014.101.421

Abstract In this study, a projection method for the monolithic interaction system of an incompressible fluid and a structure using a new algebraic splitting is proposed. The proposed method splits the monolithic equation system into the equilibrium equations and the pressure Poisson equation (PPE) algebraically using the intermediate velocity in the nonlinear iterations. Since the proposed equilibrium equation satisfies the interface condition, the proposed method is strongly coupled. Moreover, the proposed PPE enforces the incompressibility constraint. Different from previous studies, the proposed algebraic splitting never generates any Schur complement. The proposed method is applied to a channel with a flexible flap,… More >