Aknur Turgumbayeva^1,2, Gulbaram Ustenova¹, Ubaidilla Datkhayev¹, Khairolla Rahimov³, Silvijus Abramavicius^4,5, Agile Tunaityte^4,*, Kairat Zhakipbekov^1,6, Kaldanay Kozhanova¹, Saken Tulemissov⁷, OzikhanUstenova⁸, Gulmira Datkayeva⁹, Edgaras Stankevicius^1,10

Phyton-International Journal of Experimental Botany, Vol.89, No.1, pp. 137-146, 2020, DOI:10.32604/phyton.2020.07665 - 01 March 2020

Abstract In this research we present that Carthamus Tinctorius L. (gen. Asteraceae, otherwise known as Safflower) (Fig. 1) may contain agents active in Cryptococcal infections, malaria and Leishmaniasis, as treatment options are becoming scarce due to drug resistance development. Phytochemistry and pharmacological activities (antimicrobial, antimalarial, antileishmanial) of C. tinctorius L. were analyzed. The composition of volatile oil of safflower dried flowers was analyzed by gas chromatography-mass spectrophotometry with flame ionization detector (GC-FID) and in vitro sensitivity assays were performed to assess biological activity. 8 known and 3 unknown compounds were detected in the extract (Fig. 1). Then the More >

Brena Sue Haughey¹, Shelby Coral White², Michael David Seckeler²

Congenital Heart Disease, Vol.14, No.5, pp. 811-813, 2019, DOI:10.1111/chd.12809

Abstract Objective: Catheter‐associated bloodstream infections complicate and prolong hos‐ pitalizations. The incidence of catheter‐associated bloodstream infections in children undergoing congenital cardiac surgery has not been reported. This study sought to define the incidence of catheter‐associated bloodstream infections after congenital cardiac surgery in neonates and infants ≤12 months old and compare hospital out‐ comes and costs to those who underwent surgery and did not have a catheter‐associ‐ ated bloodstream infections.
Design: Retrospective review of hospital admissions between October 2013 and November 2015 for neonates and infants ≤12 months old at admission with ICD‐9 codes for congenital cardiac surgery from… More >

Sarah Tweddell, Rohit S. Loomba, David S. Cooper, Alexis L. Benscoter

Congenital Heart Disease, Vol.14, No.5, pp. 785-790, 2019, DOI:10.1111/chd.12779

Abstract Introduction: Health care‐associated infections (HAIs) increase mortality, length of stay, and cost in hospitalized patients. The incidence of and risk factors for developing HAIs in the pediatric population after cardiac surgery have been studied. This study evaluates the impact of HAIs on length of stay, inpatient mortality, and cost of hospitalization in the pediatric population after cardiac surgery.
Methods: TheKids’InpatientDatabasewasqueriedforanalysis.Patientsunder18years of age who underwent cardiac surgery from 1997 to 2012 were included. HAIs were defined as central line‐associated blood stream infections, catheter‐associated urinary tract infections, ventilator‐associated pneumonias, and surgical wound infections. Univariate analysis compared admissions with and… More >

Wei LI, Huihui GAO, Ran TAO, Lifang LIU, Shiqiang SHANG^*

BIOCELL, Vol.43, No.4, pp. 285-291, 2019, DOI:10.32604/biocell.2019.08177

Abstract As a response factor of interferon, tripartite motif (TRIM) 22 was reported to exert antiviral activity against viruses. In this study, THP-1 macrophages were infected with human cytomegalovirus (HCMV) to establish the HCMV lytic infection model. The mRNA levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) and interferonbeta (IFN-β) were significantly up-regulated in THP-1 macrophages at different infection time and titers. Moreover, for the first time, upregulation of TRIM22 expression was found during HCMV infection at both mRNA and protein levels in THP-1 macrophages. Furthermore, IFN-β could induce TRIM22 expression in THP-1 macrophages or HCMV More >

Maryam Monazzah¹, Sattar Tahmasebi Enferadi^1,*, Zohre Rabiei¹ and Alessandro Mattiello²

Phyton-International Journal of Experimental Botany, Vol.88, No.2, pp. 149-159, 2019, DOI:10.32604/phyton.2019.05053

Abstract Helianthus annuus L. as an oil seed crop is widely grown throughout the world. One of the most destructive diseases of sunflower is stem rot caused by Sclerotinia sclerotiorum. Oxalic acid is the major virulence factor of this necrotrophic pathogen. It is important to further investigate plant responses to this non-specific toxin. Therefore, in the present study, we compared the patterns of total soluble proteins and xylem morphology of partially resistant and susceptible sunflower lines after treatment with Sclerotinia culture filtrate. The basal stems of both lines were treated with 40 mM oxalic acid (pH… More >

Muhammad Shoaib Arif^1,*, Ali Raza¹, Muhammad Rafiq², Mairaj Bibi³, Rabia Fayyaz³, Mehvish Naz³, Umer Javed⁴

CMC-Computers, Materials & Continua, Vol.59, No.3, pp. 787-804, 2019, DOI:10.32604/cmc.2019.04655

Abstract In this paper, a reliable stochastic numerical analysis for typhoid fever incorporating with protection against infection has been considered. We have compared the solutions of stochastic and deterministic typhoid fever model. It has been shown that the stochastic typhoid fever model is more realistic as compared to the deterministic typhoid fever model. The effect of threshold number T* hold in stochastic typhoid fever model. The proposed framework of the stochastic non-standard finite difference scheme (SNSFD) preserves all dynamical properties like positivity, bounded-ness and dynamical consistency defined by Mickens, R. E. The stochastic numerical simulation of More >

Jonathan N. Johnson^1,2, Cindy S. Barrett³, Wayne H. Franklin⁴, Eric M. Graham⁵, Nancy J. Halnon⁶, Brandy A. Hattendorf⁷, Catherine D. Krawczeski⁸, James J. McGovern⁹, Matthew J. O’Connor¹⁰, Amy H. Schultz¹¹, Jeffrey M. Vinocur¹², Devyani Chowdhury¹³, Jeffrey B. Anderson¹⁴

Congenital Heart Disease, Vol.12, No.6, pp. 756-761, 2017, DOI:10.1111/chd.12519

Abstract Introduction: In 2012, the American College of Cardiology’s (ACC) Adult Congenital and Pediatric Cardiology Council established a program to develop quality metrics to guide ambulatory practices for pediatric cardiology. The council chose five areas on which to focus their efforts; chest pain, Kawasaki Disease, tetralogy of Fallot, transposition of the great arteries after arterial switch, and infection prevention. Here, we sought to describe the process, evaluation, and results of the Infection Prevention Committee’s metric design process.
Methods: The infection prevention metrics team consisted of 12 members from 11 institutions in North America. The group agreed to work… More >

Caibin Zeng¹, Qigui Yang¹

CMES-Computer Modeling in Engineering & Sciences, Vol.59, No.1, pp. 65-78, 2010, DOI:10.3970/cmes.2010.059.065

Abstract In this paper, a fractional order model is established to describe HIV internal viral dynamics involving HAART effect. First, the model is proved to possess non-negative solutions as desired in any population dynamics. Then, a detailed analysis is carried out to study the stability of equilibrium points. Numerical simulations are presented to illustrate the stability analysis. More >

A. LÓPEZ-HERRERA^1*, J. RUIZ-SÁENZ², Y.P. GÓEZ³, W. ZAPATA³, P.A. VELILLA³, A.E. ARANGO³, S. URCUQUI-INCHIMA³

BIOCELL, Vol.33, No.2, pp. 121-132, 2009, DOI:10.32604/biocell.2009.33.121

Abstract To determine whether fibroblasts from Blanco Orejinegro cattle, exhibit any level of resistance to infection against vesicular stomatitis virus (VSV) serotypes Indiana (VSV-I) or New Jersey (VSVNJ), 30 fibroblast cultures were phenotyped to evaluate their resistance/susceptibility. Thirty three % of Blanco Orejinegro fibroblast cultures were classified as very resistant, 50% as resistant, and 17% as susceptible to VSV-I infection, whereas 20% were classified as very resistant, 50% as resistant and 30% as susceptible to VSV-NJ infection. Therefore, there appears to be a large variation in phenotypic polymorphism among the fibroblasts to infection by VSV. To More >

Yohsuke Imai, Hitoshi Kondo, Young Ho KANG, Takuji Ishikawa Chwee Teck Lim, Takami Yamaguchi

The International Conference on Computational & Experimental Engineering and Sciences, Vol.9, No.3, pp. 205-206, 2009, DOI:10.3970/icces.2009.009.205

Abstract Malaria is one of the most serious infectious diseases on earth. We have about five hundred million patients with two million deaths. When a malaria parasite invades and matures inside a red blood cell (RBC), the infected RBC (IRBC) becomes stiffer and cytoadherent. We propose a numerical model of hemodynamics arising from malaria infection. Our model is based on a Lagrangian and free mesh method (particle) method. A spring network model is employed to compute elastic force generated by the deformation of IRBC membrane. Adhesive property of IRBCs to surrounding cells is also expressed by More >