Hong Qian^∗, Hao Ge^†

Molecular & Cellular Biomechanics, Vol.9, No.1, pp. 1-30, 2012, DOI:10.3970/mcb.2012.009.001

Abstract Biochemical reaction systems in mesoscopic volume, under sustained environmental chemical gradient(s), can have multiple stochastic attractors. Two distinct mechanisms are known for their origins: (a) Stochastic single-molecule events, such as gene expression, with slow gene on-off dynamics; and (b) nonlinear networks with feedbacks. These two mechanisms yield different volume dependence for the sojourn time of an attractor. As in the classic Arrhenius theory for temperature dependent transition rates, a landscape perspective provides a natural framework for the system's behavior. However, due to the nonequilibrium nature of the open chemical systems, the landscape, and the attractors it represents, are all themselves… More >

Rami K Korhonen^∗,†, Sang-Kuy Han^‡, Walter Herzog^‡

Molecular & Cellular Biomechanics, Vol.7, No.3, pp. 125-134, 2010, DOI:10.3970/mcb.2010.007.125

Abstract Changes in the osmotic environment cause changes in volume of isolated cells and cells in tissue explants, and the osmotic environment becomes hypotonic in cartilage diseases such as osteoarthritis (OA). However, it is not known how cells respond to a hypotonic osmotic challenge when situated in the fully intact articular cartilage.
A confocal laser scanning microscope was used to image chondrocytes of intact rabbit patellae in an isotonic (300 mOsm) and hypotonic (172 mOsm) immersion medium. Cell volumes were calculated before and 5, 15, 60, 120 and 240 minutes after the change in saline concentration. Local tissue strains and swelling… More >

Vedula S.R.K.^*, Lim T.S.^†, Hunziker W.^‡, Lim C.T.^§

Molecular & Cellular Biomechanics, Vol.5, No.3, pp. 169-182, 2008, DOI:10.3970/mcb.2008.005.169

Abstract Intercellular adhesion molecules play an important role in regulating several cellular processes such as a proliferation, migration and differentiation. They also play an important role in regulating solute diffusion across monolayers of cells. The adhesion characteristics of several intercellular adhesion molecules have been studied using various biochemical assays. However, the advent of single molecule force spectroscopy as a powerful tool to analyze the kinetics and strength of protein interactions has provided us with an opportunity to investigate these interactions at the level of a single molecule. The study of interactions involving intercellular adhesion molecules has gained importance because of the… More >

S.R.K. Vedula¹, T.S. Lim², P.J. Kausalya³, W. Hunziker³, G. Rajagopal², C.T. Lim^1,4

Molecular & Cellular Biomechanics, Vol.2, No.3, pp. 105-124, 2005, DOI:10.3970/mcb.2005.002.105

Abstract Cell-cell adhesion is an extremely important phenomenon as it influences several biologically important processes such as inflammation, cell migration, proliferation, differentiation and even cancer metastasis. Furthermore, proteins involved in cell-cell adhesion are also important from the perspective of facilitating better drug delivery across epithelia. The adhesion forces imparted by proteins involved in cell-cell adhesion have been the focus of research for sometime. However, with the advent of nanotechnological techniques such as the atomic force microscopy (AFM), we can now quantitatively probe these adhesion forces not only at the cellular but also molecular level. Here, we review the structure and function… More >

Jun Xie¹, Dapeng Sun¹, Jiaxiang Cai², Fuhong Cai^1,*

CMC-Computers, Materials & Continua, Vol.59, No.2, pp. 687-695, 2019, DOI:10.32604/cmc.2019.03658

Abstract The level of chemical oxygen demand (COD) is an important index to evaluate whether sewage meets the discharge requirements, so corresponding tests should be carried out before discharge. Fourier transform infrared spectroscopy (FTIR) and attenuated total reflectance (ATR) can detect COD in sewage effectively, which has advantages over conventional chemical analysis methods. And the selection of characteristic bands was one of the key links in the application of FTIR/ATR spectroscopy. In this work, based on the moving window partial least-squares (MWPLS) regression to select a characteristic wavelength, a method of equivalent wavelength selection was proposed combining with paired t-test equivalent… More >

Donggang Li^1,2, Alexandra Levesque², Qiang Wang^1,3,2, Agnieszka Franczak², Chun Wu¹, Jean-Paul Chopart², Jicheng He¹

CMC-Computers, Materials & Continua, Vol.30, No.3, pp. 207-218, 2012, DOI:10.3970/cmc.2012.030.207

Abstract Co/Ni bilayered films were prepared on ITO glass by electrodeposition assisted with a magnetic field up to 0.5T aligned parallel to the electrode surface. The effect of a high magnetic field annealing up to 12T on morphology and microstructure of the post-deposited films was investigated by field emission scanning electronic microscopy (FE-SEM), X-ray diffraction (XRD) and atomic force microscopy (AFM). Grain shape and grain boundary in the Co/Ni morphology were modified dramatically when the high magnetic field was applied during the annealing process. Magnetic anisotropy appeared in the films due to the preferential orientation of fcc-CoNi alloy in comparison with… More >

Zone-Ching Lin¹, Ying-Chih Hsu¹

CMC-Computers, Materials & Continua, Vol.27, No.2, pp. 143-178, 2012, DOI:10.32604/cmc.2012.027.143

Abstract This paper uses quasi-steady molecular statics method to carry out simulation of nanoscale orthogonal cutting of single-crystal copper workpiece by the diamond tools with different edge shapes. Based on the simulation results, this paper analyzes the cutting force, equivalent stress and strain, and temperature field. For the three-dimensional quasi-steady molecular statics nanocutting model used by this paper, when the cutting tool moves on a workpiece, displacement of atoms is caused due to the effects of potential on each other. After a small distance that each atom moves is directly solved by the calculated trajectory of each atom, the concept of… More >

Zone-Ching Lin¹, Ying-Chih Hsu¹

CMC-Computers, Materials & Continua, Vol.25, No.1, pp. 75-106, 2011, DOI:10.3970/cmc.2011.025.075

Abstract The three-dimensional quasi-steady molecular statics nanocutting model is used by this paper to carry out simulation analysis of nanocutting of sapphire in order to explore the effects of conical tools with different tip radii of probe and straight-line cutting at different cutting depths, on cutting force. Meanwhile, this paper uses a cutting tool of atomic force microscopy (AFM) with a probe tip similar to a semisphere to conduct nanocutting experiment of sapphire substrate. Furthermore, from the experimental results of nanocutting sapphire substrate, this paper innovatively proposes the theoretical model and equation that the specific down force energy (SDFE) during nanocutting… More >

Zhengwei Li^1,2, Jianli Wang^1,*, Tao Chen¹, Bin Wang¹, Yuanhao Wu¹

CMES-Computer Modeling in Engineering & Sciences, Vol.117, No.2, pp. 271-286, 2018, DOI:10.31614/cmc.2018.04005

Abstract With the development of adaptive optics and post restore processing techniques, large aperture ground-based telescopes can obtain high-resolution images (HRIs) of targets. The pose of the space target can be estimated from HRIs by several methods. As the target features obtained from the image are unstable, it is difficult to use existing methods for pose estimation. In this paper a method based on real-time target model matching to estimate the pose of space targets is proposed. First, the physically-constrained iterative deconvolution algorithm is used to obtain HRIs of the space target. Second, according to the 3D model, the ephemeris data,… More >

K. Abe¹, H. Fujii¹, S. Yoshimura¹

CMES-Computer Modeling in Engineering & Sciences, Vol.113, No.1, pp. 71-87, 2017, DOI:10.3970/cmes.2017.113.068

Abstract Microscopic traffic simulations are useful for solving various traffic- related problems, e.g. traffic jams and accidents, local and global environmental and energy problems, maintaining mobility in aging societies, and evacuation plan- ning for natural as well as man-made disasters. The origin-destination (OD) matrix is often used as the input to represent traffic demands into traffic simulators. In this study, we propose an indirect method for estimating the OD matrix using a traffic simulator as an internal model. The proposed method is designed to output results that are consistent with the input of the simulator. The method consists of the following… More >