Zhiguo Yong¹, Hongmei Kang¹, Falai Chen^2,*

CMES-Computer Modeling in Engineering & Sciences, Vol.138, No.1, pp. 739-760, 2024, DOI:10.32604/cmes.2023.027171

Abstract PHT-splines are defined as polynomial splines over hierarchical T-meshes with very efficient local refinement properties. The original PHT-spline basis functions constructed by the truncation mechanism have a decay phenomenon, resulting in numerical instability. The non-decay basis functions are constructed as the B-splines that are defined on the 2 × 2 tensor product meshes associated with basis vertices in Kang et al., but at the cost of losing the partition of unity. In the field of finite element analysis and topology optimization, forming the partition of unity is the default ingredient for constructing basis functions of approximate spaces. In this paper,… More > Graphic Abstract

Lu Wei, Zhong Ma^*, Chaojie Yang

CMES-Computer Modeling in Engineering & Sciences, Vol.138, No.1, pp. 981-1000, 2024, DOI:10.32604/cmes.2023.027085

Abstract The demand for adopting neural networks in resource-constrained embedded devices is continuously increasing. Quantization is one of the most promising solutions to reduce computational cost and memory storage on embedded devices. In order to reduce the complexity and overhead of deploying neural networks on Integer-only hardware, most current quantization methods use a symmetric quantization mapping strategy to quantize a floating-point neural network into an integer network. However, although symmetric quantization has the advantage of easier implementation, it is sub-optimal for cases where the range could be skewed and not symmetric. This often comes at the cost of lower accuracy. This… More > Graphic Abstract

Gagan Deep^*, Jyoti Verma

Journal on Artificial Intelligence, Vol.5, pp. 57-73, 2023, DOI:10.32604/jai.2023.043329

Abstract This research explores the increasing importance of Artificial Intelligence (AI) and Machine Learning (ML) with relation to smart cities. It discusses the AI and ML’s ability to revolutionize various aspects of urban environments, including infrastructure, governance, public safety, and sustainability. The research presents the definition and characteristics of smart cities, highlighting the key components and technologies driving initiatives for smart cities. The methodology employed in this study involved a comprehensive review of relevant literature, research papers, and reports on the subject of AI and ML in smart cities. Various sources were consulted to gather information on the integration of AI… More >

Saqlain Abbas^1,2,*, Zulkarnain Abbas³, Xiaotong Tu⁴, Yanping Zhu²

Journal on Artificial Intelligence, Vol.5, pp. 43-56, 2023, DOI:10.32604/jai.2023.040948

Abstract Structural health monitoring (SHM) is considered an effective approach to analyze the efficient working of several mechanical components. For this purpose, ultrasonic guided waves can cover long-distance and assess large infrastructures in just a single test using a small number of transducers. However, the working of the SHM mechanism can be affected by some sources of variations (i.e., environmental). To improve the final results of ultrasonic guided wave inspections, it is necessary to highlight and attenuate these environmental variations. The loading parameters, temperature and humidity have been recognized as the core environmental sources of variations that affect the SHM sensing… More >

Oliva Debnath¹, Saptarshi Debnath¹, Sreyashi Karmakar², MD Tausif Mallick³, Himadri Nath Saha^4,*

Journal on Internet of Things, Vol.5, pp. 13-43, 2023, DOI:10.32604/jiot.2023.039391

Abstract The Internet of Things (IoT) will significantly impact our social and economic lives in the near future. Many Internet of Things (IoT) applications aim to automate multiple tasks so inactive physical objects can behave independently of others. IoT devices, however, are also vulnerable, mostly because they lack the essential built-in security to thwart attackers. It is essential to perform the necessary adjustments in the structure of the IoT systems in order to create an end-to-end secure IoT environment. As a result, the IoT designs that are now in use do not completely support all of the advancements that have been… More >

LU SUN^1,2, HUAICHENG TAN¹, TING YU³, RUICHAO LIANG^4,*

Oncology Research, Vol.31, No.6, pp. 967-988, 2023, DOI:10.32604/or.2023.042309

Abstract Lung adenocarcinoma (LUAD) is the most common and deadliest subtype of lung cancer. To select more targeted and effective treatments for individuals, further advances in classifying LUAD are urgently needed. The number, type, and function of T cells in the tumor microenvironment (TME) determine the progression and treatment response of LUAD. Long noncoding RNAs (lncRNAs), may regulate T cell differentiation, development, and activation. Thus, our aim was to identify T cell-related lncRNAs (T cell-Lncs) in LUAD and to investigate whether T cell-Lncs could serve as potential stratifiers and therapeutic targets. Seven T cell-Lncs were identified to further establish the T… More >

PENGCHENG ZHANG^1,#,*, XINGLONG ZHANG^2,#, YONGFU ZHU³, YIYI CUI¹, JING XU⁴, WEIPING ZHANG^1,*

Oncology Research, Vol.31, No.6, pp. 937-953, 2023, DOI:10.32604/or.2023.030933

Abstract Polo-like kinase 1 (PLK1) plays a crucial role in cell mitosis and has been associated with necroptosis. However, the role of PLK1 and necroptosis in lung adenocarcinoma (LA) remains unclear. In this study, we analyzed The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression databases to evaluate the prognostic value and mechanistic role of PLK1 in LA. PLK1 was found to be highly expressed in LA and was positively associated with advanced disease staging and poor survival outcomes. Functional enrichment analysis showed that PLK1 was involved in cell mitosis, neurotransmitter transmission, and drug metabolism. Further analysis using single-sample gene set enrichment… More > Graphic Abstract

WEI DU¹, FANG YIN¹, YATING ZHONG¹, MINJIE LUO¹, ZHEN WANG², PENG LIN², QING LIU^2,*, HAN YANG^2,*

Oncology Research, Vol.31, No.6, pp. 929-936, 2023, DOI:10.32604/or.2023.030611

Abstract Non-small cell lung cancer (NSCLC) is a highly lethal cancer, and better treatments are urgently needed. Many studies have implicated circular RNAs (circRNAs) in the progression of multiple malignant tumors. Nonetheless, the functions of circRNAs in NSCLC remain unclear. To study new targets for the treatment of NSCLC, circRNA expression profiling was performed on NSCLC tissues and para-carcinoma nonmalignant tissues. RNA was isolated and used for circRNA sequencing. Biological studies were performed in vitro and in vivo to determine the functions of circRNAs in NSCLC, including their functions in cell proliferation and migration. How circRNAs function in NSCLC was explored… More > Graphic Abstract

EUN SOOK KIM¹, SANGHEE KIM², AREE MOON^1,*

Oncology Research, Vol.31, No.6, pp. 867-875, 2023, DOI:10.32604/or.2023.030411

Abstract Invasion and metastasis are important hallmarks of breast cancer and are the leading cause of patient mortality. Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer characterized by a poor prognosis and a lack of effective targeted therapies. The present study investigated the inhibitory effect of a novel FTY720 derivative on the invasive phenotype of TNBC cells. Here, we showed that a novel compound with an isoxazole ring, 4-(3-Decylisoxazol-5-yl)-1-hydroxy-2-(hydroxymethyl)butan-2-aminium chloride (CM2-II-173), significantly inhibited invasiveness of MDA-MB-231 TNBC cells. Expression of matrix metalloproteinase (MMP)-9 and invasiveness of MCF10A normal breast cells induced by sphingosine-1-phosphate (S1P) were reduced by CM2-II-173… More >

ARCHITTAPON NOKKEAW^1,2,3,#, PANNATHON THAMJAMRASSRI^1,2,3,#, NAPHAT CHANTARAVISOOT^1,4, PISIT TANGKIJVANICH^1,2,*, CHAIYABOOT ARIYACHET^1,2,*

Oncology Research, Vol.31, No.6, pp. 989-1005, 2023, DOI:10.32604/or.2023.030395

Abstract Hepatocellular carcinoma (HCC) is the leading cause of cancer death worldwide; nevertheless, current therapeutic options are limited or ineffective for many patients. Therefore, elucidation of molecular mechanisms in HCC biology could yield important insights for the intervention of novel therapies. Recently, various studies have reported dysregulation of long non-coding RNAs (lncRNAs) in the initiation and progression of HCC, including H19; however, the biological function of H19 in HCC remains unclear. Here, we show that knockdown of H19 disrupted HCC cell growth, impaired the G1-to-S phase transition, and promoted apoptosis, while overexpression of H19 yielded the opposite results. Screening for expression… More > Graphic Abstract