Omojola Awogbemi^1,*, Daramy Vandi Von Kallon¹, Victor Sunday Aigbodion^2,3

Journal of Renewable Materials, Vol.10, No.8, pp. 2217-2246, 2022, DOI:10.32604/jrm.2022.019152

Abstract Chicken eggshell is one of the most common wastes generated from households, restaurants and other food processing outlets. Waste Chicken Eggshells (WCES) also constitutes an environmental nuisance and ends up discarded at dumping site with no consideration of further usage. The main constituent of WCES is calcium carbonate from which calcium or calcium oxide can be extracted for various applications. This current effort reviews recently published literature on the diverse applications of WCES. The considered utilization avenues include catalysts for biofuel production, construction industry, wastewater purification, industrial sector, food industry, medical, and agricultural applications. The specific areas of application apart… More > Graphic Abstract

WEI LIANG^1,2,*, QIANG LUO^1,2,#, ZONGWEI ZHANG^1,2,#, KEJU YANG^1,2,3, ANKANG YANG^1,2, QINGJIA CHI⁴, HUAN HU⁵

BIOCELL, Vol.46, No.8, pp. 1989-2002, 2022, DOI:10.32604/biocell.2022.019300

Abstract Diabetic nephropathy (DN) is a common microvascular complication that easily leads to end-stage renal disease. It is important to explore the key biomarkers and molecular mechanisms relevant to diabetic nephropathy (DN). We used highthroughput RNA sequencing to obtain the genes related to DN glomerular tissues and healthy glomerular tissues of mice. Then we used LIMMA to analyze differentially expressed genes (DEGs) between DN and non-diabetic glomerular samples. And we performed KEGG, gene ontology functional (GO) enrichment, and gene set enrichment analysis to reveal the signaling pathway of the disease. The CIBERSORT algorithm based on support vector machine was used to… More >

ZIQIAN WANG^1,2,#, YAQI LI^1,2,#, DONGYANG WANG^1,2, YINGQIANG SHEN^1,3,4,5,*

BIOCELL, Vol.46, No.7, pp. 1599-1611, 2022, DOI:10.32604/biocell.2022.018530

Abstract Iron-dependent ferroptosis is a form of cell death dependent on iron levels. Cells that undergo ferroptosis have glutathione (GSH) deficiency, reduced Glutathione peroxidase-4 (GPX4) activity and intracellular lipid peroxidation, Mitochondria, lysosomes and many signal pathways are involved in the regulation of ferroptosis. More importantly, many tumor cells resistant to other cell death methods exhibit sensitivity to ferroptosis. Moreover, over recent years, a number of ferroptosis-induced drugs have been recommended for the treatment of malignant tumors. Therefore, the study of ferroptosis is of great significance for future cancer treatments. In this review, we discussed the metabolic process of ferroptosis, the role… More >

GIUSEPPINA AMODIO¹, VALENTINA PAGLIARA¹, PAOLO REMONDELLI^1,*, ORNELLA MOLTEDO²

BIOCELL, Vol.46, No.5, pp. 1131-1137, 2022, DOI:10.32604/biocell.2022.018638

Abstract The endoplasmic reticulum (ER) is the site of entry of all proteins that function in the secretory pathway including the extracellular environment. Because it controls the folding of newly synthesized secretory proteins, the ER is indispensable for the maintenance of proteostasis in the secretory pathway. Within the ER and, in part, in post-ER compartments, the quality control of protein folding is under the regulation of the unfolded protein response (UPR) pathways. The UPR strategy is to enhance protein folding, increase the ER degradation pathway of misfolded proteins, and allow the exit from the ER of only correctly folded proteins. The… More >

FEI CHENG^1,#, YIQIAN DING^2,#, QING XU³, WEI ZHANG³, YULAN ZHEN⁴, JING LIU⁵, SHICHENG LI¹, CHANG TU¹, GUOHUA LAI¹, JUN LAN^1,*, JINGFU CHEN^1,*

BIOCELL, Vol.46, No.4, pp. 1053-1066, 2022, DOI:10.32604/biocell.2021.012901

Abstract Previous reports have suggested that Ang-(1-7) may have a protective effect in endothelial cells against high glucose (HG)-induced cell injury thanks to a modulatory mechanism in the NF-κB signaling pathway. In this study, we have examined whether NF-κB-IL-1β and Heme oxygenase-1 (HO-1) pathways contribute to the protection of Ang-(1-7) against hyperglycemia-induced inflammation and oxidative stress in human umbilical vein endothelial cells (HUVECs). Our results indicate that time-varying exposures of HUVECs, from 1 h to 24 h, to high glucose concentrations result in an increased expression of phosphorylated (p)-p65 and HO-1 in a time-dependent manner. As an inhibitor of NF-κB, pyrrolidinedithiocarbamic… More >

TIANTIAN XU^1,#, RUILIN ZHENG^1,#, DANYANG CHEN^1,#, HAIYANG CHEN², MINGQI ZHAO¹, MIN GUO¹, YI CHEN¹, CHANGBING WANG¹, LU KUANG¹, YINGHUA LI^1,*, BING ZHU^1,*

BIOCELL, Vol.46, No.4, pp. 1033-1039, 2022, DOI:10.32604/biocell.2022.017757

Abstract Emerging evidence that Enterovirus A 71 (EV-A71) infection closely related to apoptosis. The ZVAD is a caspase inhibitor that can prevent apoptosis. The aims of this project were to evaluate the mechanism of the ZVAD inhibited EV-A71 virus and to provide experiment basis for finding new antiviral drugs. In this study, after treated with ZVAD in EV-A71 infected Vero cells, the viral replication was reduced, and the cell viability was higher than EV-A71 group. Additionally, ZVAD decreased the cell apoptosis and the level of inflammatory cytokines induced by EV-A71 in the infected Vero cells. ZVAD inhibited cell apoptosis by regulating… More >

MAURA BENEDETTI, MARIA ELISA GIULIANI, MARICA MEZZELANI, ALESSANDRO NARDI, LUCIA PITTURA, STEFANIA GORBI, FRANCESCO REGOLI

BIOCELL, Vol.46, No.1, pp. 37-49, 2022, DOI:10.32604/biocell.2022.017507

Abstract Oxidative stress is a critical condition derived from the imbalance between the generation of reactive oxygen species and the sophisticated network of antioxidant mechanisms. Several pollutants and environmental factors can affect this system through connected mechanisms, indirect relationships, and cascade effects from pre-transcriptional to catalytic level, by either enhancing intracellular ROS formation or impairing antioxidant defenses. This review summarizes the current knowledge on the pro-oxidant challenges from emerging environmental stressors threatening marine organisms, such as pharmaceuticals, microplastics and climate-related ocean changes. Emphasis will be placed on oxidative pathways, including signaling proteins and transcription factors involved in regulation of antioxidant responsiveness.… More >

Akanksha Tiwari¹, Ram Bilas Pachori^1,2, Premjit Khanganba Sanjram^1,3,4,*

CMC-Computers, Materials & Continua, Vol.70, No.2, pp. 2347-2363, 2022, DOI:10.32604/cmc.2022.020299

Abstract In performing a gaming task, mental rotation (MR) is one of the important aspects of visuospatial processing. MR involves dorsal-ventral pathways of the brain. Visual objects/models used in computer-games play a crucial role in gaming experience of the users. The visuospatial characteristics of the objects used in the computer-game influence the engagement of dorsal-ventral visual pathways. The current study investigates how the objects’ visuospatial characteristics (i.e., angular disparity and dimensionality) in an MR-based computer-game influence the cortical activities in dorsal-ventral visual pathways. Both the factors have two levels, angular disparity: convex angle (CA) vs. reflex angle (RA) and dimensionality: 2D… More >

Fabrizio Drago^*, Irma Battipaglia, Pietro Paolo Tamborrino, Luigina Porco, Camilla Calvieri, Mario Salvatore Russo, Vincenzo Pazzano, Romolo Remoli, Massimo Stefano Silvetti

Congenital Heart Disease, Vol.16, No.6, pp. 561-572, 2021, DOI:10.32604/CHD.2021.016623

Abstract Background: Cryoablation of accessory pathways (APs) is effective and very safe in children, as previously reported by our group. The aim of this retrospective study was to evaluate the current efficacy of 3D non-fluoroscopic cryoablation of right sided APs in children, comparing results obtained with the Ensite Velocity^TM and the more recent Ensite Precision^TM 3D mapping systems. Methods and Results: From January 2016 to December 2019, 102 pediatric patients [mean age 12.5 ± 2.8, 62 males (61% of total cohort)] with right APs underwent 3D non-fluoroscopic transcatheter cryoablation at our Institution. Fifteen (14.7%) patients had previously undergone catheter ablation. Acute… More >

Griselda Madrid-Delgado^1,#, Marcos Orozco-Miranda^1,#, Mario Cruz-Osorio^1,#, Ofelia Adriana Hernández-Rodríguez¹, Raúl Rodríguez-Heredia², Melchor Roa-Huerta², Graciela Dolores Avila-Quezada^1,*

Phyton-International Journal of Experimental Botany, Vol.90, No.5, pp. 1321-1338, 2021, DOI:10.32604/phyton.2021.016174

Abstract

This review highlights the key role that mycorrhizal fungi play in making phosphorus (Pi) more available to plants, including pathways of phosphorus absorption, phosphate transporters and plant-mycorrhizal fungus symbiosis, especially in conditions where the level of inorganic phosphorus (Pi) in the soil is low. Mycorrhizal fungi colonization involves a series of signaling where the plant root exudates strigolactones, while the mycorrhizal fungi release a mixture of chito-oligosaccharides and liposaccharides, that activate the symbiosis process through gene signaling pathways, and contact between the hyphae and the root. Once the symbiosis is established, the extraradical mycelium acts as an extension of the… More >