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Long noncoding RNAs as Tumorigenic Drivers and Therapeutic Targets

Submission Deadline: 30 August 2024 (closed) View: 345

Guest Editors

Tao Liu, Children’s Cancer Institute Australia & The University of New South Wales, Australia. Email: tliu@ccia.unsw.edu.au
Xu Dong Zhang, University of Newcastle Australia, Australia. Email: xu.zhang@newcastle.com.au

Summary

Long noncoding RNAs (lncRNAs) are emerging as critical tumorigenic factors and therapeutic targets in the past decade. Originally regarded as transcriptional junks, lncRNAs have been demonstrated to regulate gene transcription, mRNA stability, degradation, protein translation and stability/degradation, leading to aberrant expression of tumor suppressors and oncogenic factors. LncRNAs therefore play important roles in malignant transformation, cancer cell proliferation, survival, migration, metastasis, tumor initiation, tumor progression, and cancer cell resistance to anticancer therapies. There are several ways to target lncRNAs: suppressing gene transcription and RNA stability/decay, gene editing with CRISPR–Cas9 or CRISPR–Cas13, disrupting secondary structure, or suppressing the interaction between lncRNAs and binding proteins. Recently, small molecule compounds have been developed to block lncRNA interaction with proteins important for its decay, disrupt the lncRNA motif important for lncRNA stabilization, or block the interaction between lncRNAs and their binding proteins important for their functions. This special issue welcomes manuscript on the role of lncRNAs in tumorigenesis and lncRNA therapies.


Keywords

Long noncoding RNAs (lncRNAs); tumorigenic; therapeutic targets; oncogenic; malignant transformation

Published Papers


  • Open Access

    ARTICLE

    Long noncoding RNA LINC01106 promotes lung adenocarcinoma progression via upregulation of autophagy

    GENGYUN SUN, YIPING ZHENG, JIANFENG CAI, JIE GAO, LIE DONG, XIANGBIN ZHANG, YINGHUI HUANG
    Oncology Research, DOI:10.32604/or.2024.047626
    (This article belongs to the Special Issue: Long noncoding RNAs as Tumorigenic Drivers and Therapeutic Targets)
    Abstract Long noncoding RNA, LINC01106 exhibits high expression in lung adenocarcinoma (LUAD) tumor tissues, but its functional role and regulatory mechanism in LUAD cells remain unclear. LINC01106 expression was analyzed in LUAD tissues and its functional impact on LUAD cells was assessed. LUAD cells were silenced with sh-LINC01106 and injected into nude mice to investigate tumor growth. The downstream transcription factors and molecular mechanism were determined using the Human transcription factor database (TFDB) database and Gene Expression Profiling Interactive Analysis (GEPIA) database. Additionally, the impact of linc01106 on autophagy was analyzed by determining the expression of… More >

    Graphic Abstract

    Long noncoding RNA LINC01106 promotes lung adenocarcinoma progression via upregulation of autophagy

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