Metochalcone induces senescence-associated secretory phenotype via JAK2/STAT3 pathway in breast cancer
JIANBO ZHOU, FENG WAN, BIN XIAO, XIN LI, CHENG PENG, FU PENG
Oncology Research, Vol.32, No.5, pp. 943-953, 2024, DOI:10.32604/or.2023.044775
（This article belongs to the Special Issue:
Application of Multi-omics Analysis in Cancer Immunotherapy)
Abstract Breast and lung cancers are the leading causes of mortality and most frequently diagnosed cancers in women and men, respectively, worldwide. Although the antitumor activity of chalcones has been extensively studied, the molecular mechanisms of isoliquiritigenin analog 2', 4', 4-trihydroxychalcone (metochalcone; TEC) against carcinomas remain less well understood. In this study, we found that TEC inhibited cell proliferation of breast cancer BT549 cells and lung cancer A549 cells in a concentration-dependent manner. TEC induced cell cycle arrest in the S-phase, cell migration inhibition
in vitro, and reduced tumor growth
in vivo. Moreover, transcriptomic analysis revealed that TEC
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