Guest Editors
Prof. Alessandra Di Masi
Email: alessandra.dimasi@uniroma3.it
Affiliation: Department of Sciences, University Roma Tre, Rome, 00146, Italy.
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Research Interests: DNA repair, metabolism, cell signaling, cancer, infectious disease, immune response
Dr. Giulia Alloisio
Email: giulia.alloisio@uniroma3.it
Affiliation: Department of Sciences, University Roma Tre, Rome, 00146, Italy.
Homepage:
Research Interests: cancer, mechanotrasduction, cell signaling
Summary
Cancer cells undergo profound metabolic reprogramming to sustain uncontrolled growth, adapt to hostile microenvironments, and evade immune surveillance. In recent years, the study of cancer metabolism has revealed a complex interplay between signaling pathways, nutrient utilization, and the tumor microenvironment, highlighting metabolic adaptations as key drivers of tumor progression and therapeutic resistance. At the same time, advances in molecular biology, metabolomics, and imaging technologies have uncovered novel vulnerabilities that can be targeted pharmacologically or through combination strategies. Innovative therapeutic approaches—including small-molecule inhibitors, dietary interventions, immunometabolic modulation, and precision medicine frameworks—are now being explored to exploit metabolic dependencies in diverse cancer types.
This Special Issue aims to bring together cutting-edge research and comprehensive reviews that deepen our understanding of metabolic reprogramming in cancer and its translational potential. Contributions of interest include mechanistic studies on metabolic pathways, identification of novel metabolic targets, development of therapeutic agents, integration of metabolism with immuno-oncology, and clinical or preclinical evaluations of metabolism-based interventions.
Keywords
Cancer metabolism, metabolic reprogramming, therapeutic resistance, metabolic vulnerabilities, immunometabolism, precision oncology
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