Guest Editors
Dr. Mihaela Temelie
Email: mihaela.temelie@nipne.ro
Affiliation: Department of Life and Environmental Physics, National Institute of Physics and Nuclear Engineering "Horia Hulubei", Magurele, 077125, Romania
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Research Interests: cancer research, in vitro models, radiobiology, high LET radiation, Neurobiolgy
Dr. Diana Savu
Email: dsavu@nipne.ro
Affiliation: Department of Life and Environmental Physics, National Institute of Physics and Nuclear Engineering "Horia Hulubei", Magurele, 077125, Romania
Homepage:
Research Interests: radiobiology, hadrontherapy
Summary
Cancer cells present uncontrolled growth and invasiveness, being characterized by mutation in key pathways of DNA damage response, cell cycle regulation apoptosis, cell migration, and many others. Conventional antitumor strategies involve surgery when anatomically possible, radiation, and chemotherapy. However, the currently available drugs and radiation treatment options often present significant side effects that profoundly affect life quality. Additionally, many tumors are highly resistant to currently available drugs and radiation treatment.
Emerging treatment strategies aim to increase specificity for the cancer cells, sparing the damage in healthy tissue. These include advanced irradiation tools such as particle therapy irradiation and drug-radiation combination.
We invite researchers to contribute to this special issue by exploring the biochemical mechanisms underlying cancer cell resistance and response to treatments involving drugs and/or radiation. We also welcome studies investigating the differential mechanisms between tumor cells and normal cells, to complete the knowledge on therapeutic strategies.
Keywords
cancer, radioresistance, radiosensitisation, antitumor drugs, in vitro, molecular mechanisms
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