Guest Editors
Dr. Fabrizio De Luca
Email: fabrizio.deluca@unipv.it
Affiliation: Department of Biology and Biotechnology, Laboratory of Cell Biology and Neurobiology, University of Pavia, Pavia, 27100, Italy
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Research Interests: Neurobiology, cell biology, cell ultrastructure, oxidative stress, inflammation, cell death mechanisms, mycotherapy, phytotherapy, new psychoactive substances (NPS), neurodegenerative diseases, breast cancer, aging, senescence
Dr. Ludovica Gaiaschi
Email: ludovica.gaiaschi@unipv.it
Affiliation: Department of Biology and Biotechnology, Laboratory of Cell Biology and Neurobiology, University of Pavia, Pavia, 27100, Italy
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Research Interests: Tumor biology, experimental toxicology, neurobiology, aging, senescence, cell biology, cell ultrastructure, oxidative stress, inflammation, cell death mechanisms, DNA-damage response, drug resistance, translational medicine
Summary
A refined understanding of how cancer cells sense, process, and adapt to stimuli is emerging from the intersection of cell biology and cancer toxicology. In tumors, toxic insults, whether derived from metabolic byproducts, oxidative stress, cell death, microenvironmental constraints, or exposure to xenobiotics, profoundly shape cellular features. These pressures influence genome stability, organelle dynamics, proteostasis, redox balance, and intercellular communication, ultimately guiding tumor heterogeneity, progression, and aggressiveness.
This Special Issue focuses on basic and mechanistic studies elucidating how cancer cells respond to and cope with toxic stressors. We welcome contributions investigating DNA and chromatin damage pathways, mitochondrial and ER stress responses, autophagy and lysosomal remodeling, cell death mechanisms, and cell-cell and cell-matrix interactions under toxic conditions. Particular interest is given to work exploring how toxic stimuli alter signaling networks, metabolic checkpoints, cytoskeletal organization, intracellular trafficking, or cell fate, including different cell death pathways and senescence mechanisms.
By emphasizing fundamental cellular processes, this Special Issue aims to clarify how cancer cell physiology is sculpted.
Keywords
Cell biology, Cancer toxicology, Cellular stress responses, Organelle dysfunction, Genome and proteome integrity
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