Guest Editors
Dr. Giovanna Casili
Email: gcasili@unime.it
Affiliation: Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, 31-98166, Italy
Homepage:
Research Interests: oncology, neuroinflammation
Dr. Marika Lanza
Email: mlanza@unime.it
Affiliation: Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, 31-98166, Italy
Homepage:
Research Interests: oncology, neuroinflammation
Dr. Alessia Filippone
Email: alessia.filippone@unime.it
Affiliation: Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, 31-98166, Italy
Homepage:
Research Interests: oncology, neuroinflammation
Summary
Glioblastoma (GBM) remains one of the most aggressive and lethal forms of brain cancer, characterized by rapid progression, resistance to therapy, and a highly invasive phenotype. Recent advances in molecular oncology have highlighted the pivotal role of peptidases—enzymes involved in protein degradation and remodeling of the tumor microenvironment—in GBM pathogenesis. These enzymes contribute to tumor growth, invasion, angiogenesis, and immune evasion, making them promising therapeutic targets.
This special issue aims to gather cutting-edge research and comprehensive reviews on the role of peptidases in glioblastoma biology, with a particular focus on the development and clinical translation of peptidase inhibitors. Topics of interest include, but are not limited to, the characterization of specific peptidases involved in GBM progression, novel inhibitor design, drug delivery strategies, resistance mechanisms, and combination therapies. Special attention will be given to translational studies that bridge preclinical findings with clinical applications, as well as emerging technologies that enhance the selectivity and efficacy of peptidase-targeted treatments.
By assembling contributions from leading experts, this issue will provide a platform to advance our understanding of peptidase biology in GBM and explore new therapeutic avenues, ultimately aiming to improve patient outcomes in this challenging disease.
Keywords
gliobastoma, peptidases, tumor growth, invasion, angiogenesis and immune evasion
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