Guest Editors
Dr. Giovanni Motta
Email: giovannimotta95@yahoo.com
Affiliation: ENT Unit-Department of Mental, Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", 80131 Naples, Italy
Homepage:
Research Interests: head and neck oncology, otology and neurotology, rhinology

Summary
Dear colleagues, laryngeal carcinoma represents an exception in the oncological landscape. Although methods have been developed and employed to strive for maximum conservation, thus preserving laryngeal function (e.g., transoral laser surgery, robotic surgery), perhaps precisely due to the heightened emphasis on functional preservation, mortality rates for this tumor type have paradoxically increased rather than decreased. Furthermore, the management of this neoplasm is highly complex, as tumors with similar characteristics (e.g., same stage, same grading, same histology) often exhibit divergent clinical outcomes. Therefore, it is imperative to investigate specific markers that can complement, rather than replace, the well-established clinical and histological data in our clinical practice, providing valuable prognostic information for optimized patient management. This special issue aims to explore all the challenges and controversies encountered by head and neck surgeons, oncologists, radiation therapists, and all professionals involved in the management of this disease, from early to locally advanced/metastatic stages.
Keywords
Laryngeal cancer, Glottic Cancer, Supraglottic Cancer, Head and neck cancer, Squamous cell carcinoma, Total laryngectomy, OPHL, Radiation, Immunotherapy, Chemotherapy, Transoral laser surgery, Robotic surgery, Head and neck markers