Guest Editors
Dr. Jarosław Nuszkiewicz
Email: jnuszkiewicz@cm.umk.pl
Affiliation: Department of Medical Biology and Biochemistry, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 24 Karłowicza St., Bydgoszcz, 85-092, Poland
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Research Interests: oxidative stress; redox signaling; mitochondria; metabolic reprogramming; inflammation; adipokines; tumor microenvironment; medical biochemistry; oncology
Summary
Metabolic and inflammatory dysregulation are now recognized as key hallmarks of cancer and major determinants of tumor behavior and therapy response. Tumor cells undergo profound metabolic reprogramming, including alterations in glycolysis, lipid metabolism, mitochondrial activity, and redox balance, which support rapid proliferation, survival under stress, and resistance to treatment. In parallel, chronic low-grade inflammation driven by cytokines, adipokines, immune-metabolic interactions, and microenvironmental stressors promotes angiogenesis, immune escape, genomic instability, and metastatic potential. Together, these interconnected pathways form a dynamic metabolic–inflammatory network that shapes the tumor microenvironment and reveals multiple opportunities for therapeutic intervention.
With this Special Issue, I aim to provide a platform for high-quality original research and review articles exploring how metabolic and inflammatory abnormalities contribute to cancer initiation, progression, and therapeutic outcomes. I particularly welcome submissions addressing molecular mechanisms, pathway-targeted therapies, immunometabolic regulation, adipokine biology, ferroptosis and lipid peroxidation, microbiota-driven metabolic inflammation, biomarker discovery, and translational approaches integrating metabolic–inflammatory profiling into precision oncology.
By bringing together multidisciplinary contributions from basic, translational, and clinical research, I hope to stimulate the development of innovative therapeutic strategies targeting metabolic and inflammatory axes in cancer.
Keywords
metabolic dysregulation, inflammation, cancer therapeutics, immunometabolism, adipokines, redox signaling, ferroptosis, tumor microenvironment
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