Guest Editors
Dr. Fabio Grizzi
Email: fabio.grizzi@humanitasresearch.it
Affiliation: Department of Immunology and Inflammation, IRCCS Humanitas Research Hospital, Milan, 20089, Italy
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Research Interests: cancers of diverse histologic origins, tissue organization, tumor therapeutic strategies
Summary
Although there have been improvements in prevention, early detection, and treatment, urogenital cancers continue to pose a major public health challenge. From a physical perspective, carcinogenesis can be viewed as a dynamic process progressing through multiple states, governed by multiscale events from genetic to organismal levels. Over the past 35 years, despite significant advances in molecular and cellular biology, the mechanisms underlying neoplastic initiation, progression and metastasis remain under debate. Treatment resistance remains a major challenge, strongly influenced by the tumor microenvironment, a complex network of various cell types interacting to drive progression and dissemination to distant sites. Advances in understanding urogenital cancer biology and immunosuppression have shifted treatment paradigms from traditional chemotherapy to targeted and immunotherapies. Yet, their efficacy is often limited, with many patients failing to respond and relapse driven by acquired resistance. Additionally, serious immune-related adverse effects are frequently observed. To address these issues, current approaches focus on combination therapies and the development of novel immunotherapeutic strategies. This special topic aims to share original research articles, brief reports, and reviews that examine urogenital cancers as complex systems, focusing on the molecular, cellular, and physical mechanisms underlying their behavior. Integrating this new knowledge offers the potential to reveal novel properties, deepen our understanding of underlying dynamics, and identify new avenues for targeted therapy.
Keywords
urogenital cancers, bladder, prostate, testis, kidney, complexity, treatment resistance, tumor microenvironment, immunotherapy, vaccines.
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