Guest Editors
Dr. Virginia Valentini
Email: virginia.valentini@uniroma1.it
Affiliation: Department of Molecular Medicine, Sapienza University of Rome, Rome, 00161, Italy
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Research Interests: Breast Cancer, Male Breast Cancer, genetic susceptibility, molecular characterization of cancer, potential prognostic and/or predictive biomarkers, innovative and personalized preventive and therapeutic strategies.
Dr. Agostino Bucalo
Email: agostino.bucalo@uniroma1.it
Affiliation: Department of Molecular Medicine, Sapienza University of Rome, Rome, 00161, Italy
Homepage:
Research Interests: Male breast cancer, NGS of gene panels, genetic predisposition to breast cancer
Summary
This special issue explores the impact of the characterization and integration of molecular biomarkers in the classification and treatment of breast cancer (BC). Despite advances in therapeutics and improved overall survival rates, the mortality rate from BC remains a significant global challenge. Research into the genetic and epigenetic landscape of BC is expanding thanks to new technologies, and molecular biomarkers are increasingly influencing its diagnosis and treatment.
New therapeutic approaches have emerged through the validation of specific biomarkers, improving treatment outcomes in female BC patients. On the other hand, clinical management and therapeutic options for male BC patients are still largely based on female BC research, leading to poorer outcomes for male patients due to gender-specific differences.
Another central theme is the use of Next Generation Sequencing to identify novel susceptibility genes and therapeutic biomarkers, which are crucial for personalized therapy. A deeper understanding of molecular genetics enables early diagnosis, preventive strategies, and personalized treatments, even for male patients.
This special issue invites researchers to submit original research articles and reviews exploring these topics, including advanced genetic studies, innovative methods, and personalized therapeutic approaches for both female and male BC patients.
Keywords
Female and male breast cancer; Hereditary cancer; Breast cancer risk; Cancer genetics; Molecular oncology; Tumor profiling; Next Generation Sequencing; Prognostic and/or predictive biomarkers; Circulating miRNA; Personalized treatment
Published Papers
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