Special Issues
Table of Content

Mechanisms of Reactive Oxygen Species Modulation in Cancer Therapy

Submission Deadline: 30 September 2025 (closed) View: 460 Submit to Journal

Guest Editors

Prof. Seung ho Baek

Email: baekone99@gmail.com  

Affiliation: College of Korean Medicine, Dongguk University, 32 Dongguk-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do 10326, Korea.

Homepage:

Research Interests: Cancer Hyperthermia, ROS, Heat shock response


Summary

Reactive oxygen species (ROS) are critical mediators in cancer therapeutics, exhibiting a dual role in facilitating cytotoxic effects and contributing to therapeutic resistance. Hyperthermia, an emerging adjunctive modality, induces ROS production, eliciting complex cellular responses in cancer cells. This Special Issue seeks to elucidate the molecular mechanisms governing ROS modulation in hyperthermia and other anticancer therapies. Contributions focusing on the regulation of cancer cell responses, the interplay between ROS and therapeutic efficacy, and strategies to mitigate resistance are encouraged to enhance the translational potential of ROS-targeted approaches in oncology.


Keywords

Reactive oxygen species (ROS), Heat shock responses, Anticancer therapy mechanisms, ROS modulation strategies, Cellular stress pathways, Cancer cell resistance mechanisms, Adjunctive oncological treatments, Translational oncology research

Published Papers


  • Open Access

    ARTICLE

    C-Phycocyanin–Cisplatin Combination Targeting Redox Balance for Enhanced Efficacy Against Glioblastoma Cells

    Rym Akrout, Ludovic Leloup, Khouloud Ayed, Fabrice Parat, Sami Zekri, Wassim Y. Almawi, Rahma Boughriba, Hanen Attia, Olfa Masmoudi-Kouki, Hervé Kovacic, Asma Gati
    Oncology Research, Vol.33, No.12, pp. 3887-3906, 2025, DOI:10.32604/or.2025.070729
    (This article belongs to the Special Issue: Mechanisms of Reactive Oxygen Species Modulation in Cancer Therapy)
    Abstract Objectives: Cisplatin (CDDP) therapy for glioblastoma (GBM) is linked with several limitations, which include poor penetration of the blood-brain barrier (BBB), systemic toxicity, and the development of drug resistance mechanisms implicating oxidative stress dysregulation and compromised apoptotic pathways. This study evaluates C-Phycocyanin (C-PC) as a potential adjuvant to enhance CDDP efficacy by modulating redox balance and apoptosis. Methods: GBM cells (U87 and U87-EGFRvIII) were treated with CDDP, C-PC, or their combination. Cell viability was assessed by MTT assay; apoptosis was evaluated by DAPI staining and Western blot analysis of cleaved Caspase-3 and poly (ADP-ribose) polymerase… More >

    Graphic Abstract

    C-Phycocyanin–Cisplatin Combination Targeting Redox Balance for Enhanced Efficacy Against Glioblastoma Cells

Share Link