Guest Editors
Dr. Lin Qi
Email: qi.lin@csu.edu.cn
Affiliation: Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, China
Homepage:
Research Interests: epigenetics, epitranscriptomics, nanomedicine
Dr. Fang Fang
Email: f.fang@nus.edu.sg
Affiliation: Department of Diagnostic Radiology, National University of Singapore, Singapore, Singapore
Homepage:
Research Interests: nanomedicine, drug delivery, metabolic regulation, disease theranostics
Summary
Cancer development and therapeutic response are governed not only by genetic alterations but also by dynamic regulatory mechanisms at the epigenetic and epitranscriptomic levels. In recent years, increasing evidence has demonstrated that DNA methylation, histone modifications, chromatin remodeling, and diverse RNA modifications collectively shape tumor initiation, progression, metastasis, immune evasion, and drug resistance. In particular, epitranscriptomic regulation, represented by RNA modifications such as m6A, m5C, m7G, pseudouridylation, and A-to-I editing, has emerged as a rapidly evolving field that provides new insights into post-transcriptional control in cancer.
This Special Issue aims to highlight recent advances in understanding how epigenetic and epitranscriptomic mechanisms contribute to cancer biology and how these processes may be exploited for therapeutic intervention. We welcome original research articles, reviews, and perspectives addressing molecular mechanisms, multi-omics analyses, biomarker discovery, tumor microenvironment regulation, therapeutic resistance, and the development of epigenetic- or RNA modification-targeted strategies. Studies exploring the crosstalk between epigenetic and epitranscriptomic pathways, as well as their translational relevance in precision oncology, are particularly encouraged.
By bringing together cutting-edge discoveries in this rapidly expanding area, this Special Issue will provide a timely platform for advancing both mechanistic understanding and therapeutic innovation in cancer research.
Keywords
cancer biology, epigenetics, epitranscriptomics, RNA modifications, DNA methylation, histone modifications
Login
Register
Submit a Paper
Propose a Special lssue