Guest Editor(s)
Dr. Daniel Gabriel Pons
Email: d.pons@uib.es
Affiliation: Department of Fundamental Biology and Health Sciences, University of Balearic Islands, Palma, Spain
Homepage:
Research Interests: biomarkers, treatment resistance, tumor microenvironment
Dr. Margalida Torrens-Mas
Email: lida.torrens@uib.es
Affiliation: Department of Fundamental Biology and Health Sciences, University of Balearic Islands, Palma, Spain
Homepage:
Research Interests: biomarkers, treatment resistance, tumor microenvironment
Summary
Chronic inflammation is a well-established hallmark of cancer and plays a critical role in tumor initiation, progression, metastasis, and resistance to therapy. Increasing evidence indicates that inflammatory signaling is tightly interconnected with oxidative stress, mitochondrial dysfunction, and metabolic reprogramming within the tumor microenvironment (TME). These processes collectively shape tumor behavior, influence epithelial–mesenchymal transition (EMT), modulate immune cell infiltration, and determine patient prognosis.
This Special Issue aims to gather original research articles and comprehensive reviews addressing the molecular and cellular mechanisms linking inflammation, redox imbalance, and tumor microenvironment dynamics across different cancer types. Particular emphasis will be placed on studies exploring cytokine signaling, ROS-dependent pathways, mitochondrial regulation, immune–tumor crosstalk, adjacent non-tumor tissue remodeling, and the identification of novel prognostic biomarkers or therapeutic targets.
We welcome translational approaches integrating patient-derived samples, in vitro and in vivo models, as well as bioinformatic analyses. Understanding how inflammatory and oxidative networks cooperate to promote cancer progression may provide innovative strategies for precision oncology and improved therapeutic interventions.
Keywords
tumor microenvironment, inflammation, oxidative stress, mitochondrial dysfunction, therapy resistance
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