Guest Editors
Prof. Petra Korać
Email: petra.korac@biol.pmf.hr
Affiliation: Department of Biology, Faculty of Science, University of Zagreb, Zagreb, Croatia
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Research Interests: medical genetics, molecular diagnostics, molecular pathology, lymphoma development, microenvironmental influences on tumor behaviour
Summary
Circadian rhythm disruption is increasingly recognized as a modifier of lymphoma biology – along with the genetic basis, environmental and epigenetic influences are proving to bring significant effect on lymphomagenesis. Altered 24-hour rhythm can contribute to changes in immune surveillance and deregulate clock-controlled pathways involved in cell cycle progression, DNA repair, apoptosis, and metabolism. Core circadian regulators, including CLOCK, BMAL1, PER, and CRY genes, govern lymphocyte proliferation and inflammatory signaling; their altered expression or epigenetic modification can promote malignant transformation and tumor progression.
In this Special Issue, we welcome original studies and focused reviews addressing how circadian dysregulation shapes lymphoma initiation, aggressiveness, treatment response, and disease evolution. Topics of interest include circadian clock gene alterations, circadian–immune interactions within the tumor microenvironment, epigenetic reprogramming, and chronotherapy approaches that optimize treatment timing. Submissions integrating molecular profiling and clinical outcomes — especially those identifying predictive biomarkers or possible therapy targets — are strongly encouraged. By linking circadian mechanisms to therapeutic optimization, this collection aims to advance and improve outcomes for patients with lymphoma.
Keywords
circadian rhythm, lymphoma development, targeted therapy, biomarkers, clock genes
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