Guest Editors
Prof. Antonio Santisteban-Espejo
Email: antonio.santisteban@uca.es
Affiliation: Department of Medicine and Surgery, University of Cadiz, Andalucía, Spain
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Research Interests: cancer biology, hodgkin lymphoma, eco-oncology, tumor microenvironment
Summary
Epigenetics encompasses the study of DNA methylation, histone modification, and non-coding RNAs. Along with the acquisition of proliferative advantage due to mutational alterations, cancer biology is governed by epigenetic reprogramming, where genes such as TET2, EZH2, IDH1, IDH2, DNMT3A, and ASXL1 play an essential role. In particular, alterations in epigenetic mechanisms contribute to the pathogenesis of numerous hematological malignancies. Recently, the concept of nonmutational epigenetic reprogramming in cancer has been linked to the composition, dynamics and structure of the tumor microenvironment (TME). In this sense, the components of the TME (cancer-associated fibroblasts, innate immune cells, endothelial cells and pericytes) undergo epigenetic modifications that contribute to the selection of clones best adapted to the hostile conditions of the environment caused by antineoplastic agents. The bioecology of cancer, therefore, includes epigenetic modifications of TME components. This special issue focuses on both epigenetic reprogramming and the role of the TME in hematological malignancies, and aims to contribute to the development of new therapeutic targets based on knowledge of their role in the development and progression of hematological cancer.
Keywords
epigenetics, tumor microenvironment, hematological cancer, target therapies
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