At present, the world has entered the era of the Industrial Revolution 4.0 (RI4), an era in which everything is associated with technology. This RI4 era prioritizes work automation using technology, such as the use of the Internet of Think (IoT). The COVID-19 pandemic has provided shock therapy for the world of education because face-to-face education cannot be carried out as usual. This certainly has an impact on the learning process. Using AI/ML/IoT/BigData techniques in education, providing optimal solution becomes important. It aims to find new challenges and overcome the difficulties of new models/techniques of learning and learning process using AI/ML/IoT/BigData to achieve learning goals. This calls for bringing new ideas in AI/ML/IoT/BigData based on COVID-19 and RI 4.0. which will provide value to researchers and scientists. The proposal aims to collect innovative and unpublished work that focuses on methods and technologies suitable for use in the learning process, or other online learning models for COVID-19 and RI 4.0. This special issue provides an opportunity for researchers around the world to share their new ideas in an interesting field.