Guest Editors
Associate Prof. Gionata Fragomeni
Email: fragomeni@unicz.it
Affiliation: Medical and Surgical Science Department, Magna Graecia University, Catanzaro, 88100, ITALY
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Research Interests: CFD (Computational Fluid Dynamics); ECMO (ExtraCorporeal Membrane Oxygenation); Cardiovascular mechanics; Artificial Organs
Summary
The intersection of fluid dynamics and bioengineering is becoming increasingly essential in the study and numerical simulation of medical devices and biological materials. These systems operate within highly complex physiological environments, where the interaction between biological tissues, fluids, and engineered components must be precisely understood and controlled. Accurately modeling such systems is crucial for optimizing medical device performance, predicting physiological responses, and advancing regenerative medicine.
Medical devices often function in dynamic biological settings that require sophisticated multi-physics models, capturing the interplay between fluid dynamics, solid mechanics, electrophysiology, and perfusion. The behavior of blood flow in artificial valves, drug transport through tissue, and the mechanical properties of bioengineered scaffolds all depend on the intricate relationship between fluid forces and biological materials. To effectively model these interactions, state-of-the-art numerical techniques—such as model reduction, uncertainty quantification, inverse problem-solving, and advanced discretization methods—are essential. At the same time, integrating these models with clinical data and validating them through experimental studies is crucial for bridging the gap between theoretical predictions and real-world applications.
Beyond medical devices, fluid dynamics plays a fundamental role in the development of biopharmaceuticals and biotechnologies. Many emerging therapies, such as cell-based treatments and tissue-engineered grafts, rely on a deep understanding of biological material behavior under fluid flow conditions. For example, microfluidic platforms enable precise manipulation of cells and biomolecules, paving the way for breakthroughs in drug delivery, organ-on-a-chip systems, and personalized medicine. Likewise, the controlled flow of biofluids is integral to bioreactor design, where the growth of engineered tissues depends on optimized nutrient transport and shear stress conditions.
As biotechnology continues to evolve, fostering a research ecosystem that seamlessly integrates advanced mathematical modeling, biological material characterization, and clinical application is imperative. Strengthening the synergy between fluid dynamics, bioengineering, and computational science will enable the development of next-generation biotechnological therapies and biomedical devices, ultimately improving patient care and advancing regenerative medicine.
Keywords
CFD; ECMO (ExtraCorporeal Membrane Oxygenation); Cardiovascular mechanics; Artificial Organs
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