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ARTICLE

Targeting Oncogenic lncRNA KRT7-AS to Induce Ferroptosis Suppresses Ovarian Cancer Progression

Yan Zhu1,#, Bin Guan1,#, Wencai Guan1, Jihong Zhang1, Shiyu Wang1, Jimin Shi1, Wei Fan1, Qi Lu2,3, Lingyun Zhang4,5,*, Guoxiong Xu1,2,*
1 Research Center for Clinical Medicine, Jinshan Hospital, Fudan University, Shanghai, China
2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
3 Department of Obstetrics and Gynecology, Jinshan Hospital, Fudan University, Shanghai, China
4 Department of Medical Oncology, Shanghai Geriatric Medical Center, Shanghai, China
5 Department of Medical Oncology, Zhongshan Hospital, Fudan University, Shanghai, China
* Corresponding Author: Lingyun Zhang. Email: email; Guoxiong Xu. Email: email
# These authors contributed equally to this work
(This article belongs to the Special Issue: New Advance in Gynecologic Oncology)

Oncology Research https://doi.org/10.32604/or.2026.075241

Received 28 October 2025; Accepted 26 January 2026; Published online 13 February 2026

Abstract

Background: Ovarian cancer poses the greatest threat to survival among gynecologic cancers in women. Long non-coding RNAs (lncRNAs) have emerged as critical regulators in oncogenesis. The current study aimed to elucidate the function and regulatory mechanism of lncRNA KRT7-AS in ovarian cancer. Methods: The clinical significance of KRT7-AS was evaluated through bioinformatics analysis of data from public repositories. KRT7-AS expression was examined by RT-qPCR and fluorescence in situ hybridization. The function analyses were conducted using assays for cell proliferation, migration, invasion, wound healing, and colony formation. Assessment of cell cycle and apoptosis was performed using flow cytometry. Mitochondrial membrane potential (MMP), reactive oxygen species (ROS), lipid peroxidation, and ferrous iron (Fe2+) levels were measured with specific kits. Tumor growth was assessed using a xenograft mouse model. Results: Patients exhibiting high KRT7-AS expression had a significantly lower survival rate. Functional assays demonstrated that KRT7-AS overexpression enhanced tumorigenic behaviors, including cell proliferation, invasion, and metastasis, whereas its knockdown suppressed these malignant phenotypes. KRT7-AS depletion induced ferroptosis, as indicated by increased MMP and ROS levels, and the accumulation of lipid peroxidation and Fe2+. In rescue experiments, the ferroptosis inhibitor ferrostatin-1 reversed the reduction in cell viability caused by KRT7-AS knockdown. Finally, in vivo studies showed that KRT7-AS knockdown inhibited tumor growth and modulated the expression of ferroptosis-related proteins by elevating ACSL4 and reducing GPX4. Conclusions: These findings suggest that KRT7-AS has potential as a diagnostic biomarker for ovarian cancer. Targeting KRT7-AS to induce ferroptosis may represent a promising therapeutic strategy for suppressing ovarian cancer progression.

Keywords

Biomarker; ferroptosis; non-coding RNA; oncogenesis; tumor suppression

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