Guest Editors
Dr. Haiyang Wu
Email: wuhaiyang2021@tmu.edu.cn
Affiliation: Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
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Research Interests: bone tumor microenvironment, tumor-associated macrophages, immune checkpoint inhibitors, osteoimmunology
Prof. Dr. Cheng Li
Email: lichengcharite@gmail.com
Affiliation: 1. Department of Spine Surgery, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China
2. Center for Musculoskeletal Surgery (CMSC), Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt University of Berlin, Berlin Institute of Health, Berlin, Germany
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Research Interests: bone tumor microenvironment, bone infection
Summary
The immune microenvironment of bone tumors represents a dynamic and complex ecosystem that critically influences tumor initiation, progression, metastasis, and response to therapy. This special issue aims to dissect the multifaceted roles of immune cells, including tumor-associated macrophages, T cells, myeloid-derived suppressor cells, and osteoclasts, within the unique mineralized matrix of bone. We seek to explore the intricate crosstalk between tumor cells, immune infiltrates, and stromal components that fosters immunosuppression or, conversely, anti-tumor immunity. Contributions are invited that address fundamental mechanisms of immune evasion, the role of inflammatory signaling and osteoimmunology, and novel biomarkers within the bone tumor niche. A key focus will be on translational and clinical research, highlighting emerging immunotherapeutic strategies, such as checkpoint blockade, CAR-T cells, and macrophage reprogramming, for primary bone sarcomas and bone metastases. This collection aims to provide a comprehensive overview that bridges basic science with clinical innovation, offering new perspectives for overcoming therapeutic resistance and improving outcomes for patients with skeletal malignancies.
Keywords
bone tumor microenvironment, tumor-associated macrophages, immune checkpoint inhibitors, osteoimmunology, immunosuppression, immunotherapy, bone metastasis, sarcoma, myeloid-derived suppressor cells
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