Guest Editor(s)
Dr. Sabrina Tosi
Email: sabrina.tosi@brunel.ac.uk
Affiliation: Department of Biosciences, Brunel University of London, Uxbridge, United Kingdom
Homepage:
Research Interests: chromosome biology, cancer, leukaemia
Dr. Annabelle Lewis
Email: annabelle.lewis@brunel.ac.uk
Affiliation: Department of Biosciences, Brunel University of London, Uxbridge, United Kingdom
Homepage:
Research Interests: colorectal cancer, cancer drug resistance, cancer genetics and gene regulation
Summary
The spatial organisation of the genome within the nucleus is now recognised as a fundamental regulator of gene expression, genome stability, and cellular identity. Beyond the linear DNA sequence, the three-dimensional (3D) architecture of chromatin—encompassing nucleosomes, chromatin loops, topologically associating domains (TADs) and chromosome territories—ensures precise coordination of transcriptional programmes governing pathways such as cellular proliferation and DNA repair. Disruption of this highly ordered 3D structure is increasingly implicated in cancer initiation and progression.
In cancer cells, alterations in genome organisation arise from genetic mutations, structural rearrangements, and epigenetic dysregulation, leading to aberrant enhancer–promoter interactions, transcriptional rewiring, and chromosomal instability. These changes not only drive tumour heterogeneity and evolution but also contribute to therapy resistance and disease relapse. Furthermore, abnormal chromatin organisation and nuclear architecture are emerging as clinically relevant biomarkers, reflecting tumour aggressiveness and patient prognosis.
This Special Issue aims to bring together cutting-edge research and reviews exploring the mechanisms governing and dependent on genome organisation in cancer, from molecular and cellular insights to translational applications. We welcome contributions addressing technological advances in genome architecture mapping, the interplay between chromatin dynamics and oncogenic signalling, and emerging therapeutic strategies targeting the 3D genome. Together, these studies will advance our understanding of cancer biology and reveal new opportunities for precision medicine.
Keywords
cancer, cancer progression, transcriptional dysregulation, therapeutic targets,3D genome organization
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