Guest Editors
Assist. Prof./Dr. Chenyu Sun
Email: drsunchenyu@yeah.net
Affiliation: Division of Public Health, Infectious Diseases, and Occupational Medicine, Mayo Clinic, United States
Mayo Clinic School of Graduate Medical Education, Mayo Clinic College of Medicine and Science, 200 First Street SW, Rochester, MN 55905, USA
School of Public Health, University of Minnesota-Twin Cities, 420 Delaware St SE, Minneapolis, MN 55455, USA
Homepage:
Research Interests: Evidence-based medicine, preventive medicine and public heath, oncology, gastroeneterology
Assist. Prof./Dr. Yuting Huang
Email: huang.yuting@mayo.edu
Affiliation: Division of Gastroenterology & Hepatology, Mayo Clinic Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224, USA
Homepage:
Research Interests: Gastroeneterology, cancer immunology, stem cell research, gene therapy
Dr. Raveena Manem
Email: raveena.manem25@gmail.com
Affiliation: Department of Hospital medicine, Regional Medical Center, San Jose, 95116, United States
Homepage:
Research Interests: Hemotology and Oncology, internal medicine
Assist. Prof./Dr. Na Hyun Kim
Email: kimnh@uw.edu
Affiliation: Division of Hematology and Oncology, Department of Medicine, University of Washington, Fred Hutch at Overlake Cancer Center, 1135 116th Ave. NE, Suite 250, Bellevue, WA 98004, USA
Homepage:
Research Interests: Medical oncology, hematology
Summary
This Special Issue aims to highlight recent advances in experimental, translational, and clinical research on immunotherapy for gastrointestinal (GI) cancers, including esophageal, gastric, colorectal, hepatic, pancreatic, and other GI-related malignancies. Emphasizing mechanistic, preclinical, translational, and clinical investigations, this issue seeks to showcase studies that elucidate the molecular basis of immune regulation, tumor–immune interactions, and therapeutic response in GI tumors.
We welcome original research and reviews focusing on the mechanisms of immune checkpoint blockade, modulation of the tumor immune microenvironment, resistance to immunotherapy, and strategies to enhance antitumor immunity. Studies exploring novel immunotherapeutic targets, cytokine regulation, oncolytic viruses, cancer vaccines, or adoptive cell therapies-supported by in vitro, in vivo, preclinical, translational, or clinical data-are highly encouraged.
This Special Issue also invites integrative studies that bridge laboratory findings with patient-derived or clinical evidence to identify predictive biomarkers, optimize therapeutic combinations, and advance personalized immunotherapy for GI cancers. By uniting experimental, translational, and clinical perspectives, this collection will deepen mechanistic understanding and foster the development of more effective immune-based strategies for gastrointestinal oncology.
Keywords
gastrointestinal (GI) cancers, evidence-based medicine, translational research, biomarker discovery, predictive modeling, real-world evidence
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