Guest Editors
Dr. Zaoqu Liu
Email: liuzaoqu@163.com
Affiliation: Institute of Basic Medical Sciences, Peking Union Medical College (PUMC), Beijing, China
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Research Interests: cancer immunology, immunogenomics, multi-omics sequencing
Dr. Yijing Su
Email: yijingsu@pennmedicine.upenn.edu
Affiliation: University of Pennsylvania School of Dental Medicine, Philadelphia, PA, USA
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Research Interests: tumor immunology, functional genomics, single-cell biology, epigenetics
Summary
1. A key determinant of anti-tumor immunity lies in the molecular basis of antigen presentation and immune recognition, including tumor mutational burden, HLA polymorphism and loss, defects in antigen processing/presentation pathways, and dynamic TCR/BCR repertoire remodeling. With advances in WES/WGS, single-cell transcriptomics with V(D)J profiling, immunopeptidomics, and spatial omics, it is now possible to map neoantigen landscapes and immune evasion mechanisms across cancer types and translate these insights into validated stratification biomarkers and predictive tools for immunotherapy response.
2. This Special Issue focuses on methodological innovations and translational applications of cancer immunogenomics and immune multi-omics sequencing. We welcome cross-cancer studies, emphasizing external validation, reproducible pipelines, and mechanistic interpretability. Topics include neoantigen discovery and validation, HLA/antigen presentation abnormalities, immune repertoire and clonal evolution, immune evasion and tolerance, and stratification/diagnostic modeling to enable personalized immunotherapy and vaccine strategies.
3. Suggested themes include:
(1) Neoantigen prediction with immunopeptidomics validation and vaccine target prioritization
(2) HLA loss/LOH and defects in antigen processing/presentation (e.g., TAP, B2M)
(3) Single-cell immune repertoire (scRNA-seq + V(D)J) and clonal dynamics
(4) Mutational landscapes/structural variants shaping immune recognition
(5) Immune evasion via antigen presentation defects, immunoediting, and tolerance
(6) Cross-cancer immunogenomic subtyping and stratification biomarkers
(7) Spatial omics linking antigen presentation with immune cell localization
(8) Multi-omics fusion for immunotherapy response prediction (explainable, externally validated)
Keywords
immunogenomics, neoantigens, HLA, antigen presentation, immune evasion, TCR/BCR repertoire, immunopeptidomics, single-cell sequencing, spatial omics, precision stratification
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