Guest Editors
Dr. Vincenzo Fiorentino
Email: vincenzo.fiorentino@unime.it
Affiliation: Anatomic Pathology Unit, Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, Messina, 98125, Italy
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Research Interests: molecular biology, liquid biopsy, immunohistochemistry, predictive markers, endometrial carcinoma
Summary
Understanding cancer at the molecular level is crucial to improving diagnosis, prognosis, and therapy across all tumor types. Advances in genomics, epigenetics, transcriptomics, proteomics, and tumor microenvironment profiling have revealed common mechanistic principles underlying tumor initiation, progression, immune escape, therapeutic resistance, and metastatic behavior. At the same time, particular molecular vulnerabilities continue to emerge as targets for precision medicine.
This Special Issue aims to gather high-quality original research and comprehensive reviews that address the molecular foundations of solid tumors, with an emphasis on pathways that transcend traditional histological boundaries. Topics of interest include oncogenic signaling networks, epigenetic regulation, RNA- and protein-based biomarkers, tumor–immune interactions, microenvironment-mediated resistance, and novel therapeutic approaches derived from these findings. By integrating evidence from different tumor types, this Special Issue seeks to highlight convergent mechanisms and innovative translational strategies that can accelerate the development of targeted therapies and more individualized clinical management.
We welcome contributions from basic, translational, and clinical researchers working across the spectrum of solid malignancies.
Keywords
molecular oncology, tumor microenvironment, biomarkers, precision oncology, therapeutic targets
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