Guest Editors
Assist. Prof. Xiaowen Mao
Email: susanmao@um.edu.mo
Affiliation: State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China
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Research Interests: cancer biology, liver complications, traditional chinese medicine
Summary
Tumor occurrence, development, and therapeutic response depend on the synergistic interaction between tumor cells and tumor microenvironment (TME). Oncogene abnormalities and chemotherapy efficacy/resistance are closely related to TME's cellular composition and spatial interaction. Traditional techniques cannot precisely analyze TME's multi-molecular and multi-cell characteristics, leaving related mechanisms unclear. Advanced technologies overcome these limitations, enabling single-cell resolution analysis. This special issue integrates these technologies to explore the oncogene-TME-chemotherapy interaction, bridging basic research and clinical translation to provide new personalized tumor treatment strategies.
1. Integrate advanced technologies' application in tumor research and promote their standardization and clinical transformation.
2. Clarify oncogenes' regulatory mechanisms on TME and their association with chemotherapy resistance.
3. Explore chemotherapy's TME remodeling effect and its impact on oncogene expression and chemotherapy sensitivity.
4. Gather innovative research regarding the involvement of oncogenes in the TME and the association with chemotherapy to support personalized chemotherapy.
5. Bridge basic and clinical research to promote TME/oncogene markers' application in efficacy prediction and resistance monitoring.
Keywords
tumor microenvironment, oncogene, cancer therapy
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