Guest Editor(s)
Prof. Giuseppe Gullo
Email: gullogiuseppe@libero.it
Affiliation: Department of Obstetrics and Gynecology, AOOR Villa Sofia-Cervello, University of Palermo, Palermo, Italy
Homepage:
Research Interests: ovarian cancer, molecular mechanisms, reproductive tract malignancies, gynecologic cancer biology, reproductive biology
Prof. Vito Chiantera
Email: vito.chiantera@unicampania.it
Affiliation: 1. Obstetrics and Gynecology Unit, Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy
2. Unit of Gynecologic Oncology, National Cancer Institute - IRCCS - Fondazione "G. Pascale", Naples, Italy
Homepage:
Research Interests: ovarian cancer, gynecologic malignancies, endometrial cancer
Summary
This Special Issue focuses on the molecular connections between normal reproductive processes and the development of reproductive tract cancers. Reproductive biology shares key pathways with oncogenesis, such as hormone signaling, DNA repair, inflammation, and epithelial-mesenchymal transition. We invite original research and review articles that explore these links and translate them into therapeutic innovations. Topics of interest include:
· Hormonal drivers of ovarian, endometrial, and breast cancers
· DNA repair defects (e.g., BRCA, HRD) and PARP inhibitor strategies
· Endometriosis-associated ovarian carcinogenesis
· Immunotherapy and targeted agents in gynecologic malignancies
· Cancer stem cells and drug resistance mechanisms
· Predictive biomarkers for precision oncology
This Special Issue welcomes mechanistic studies, drug development reports, and translational research that bridge reproductive biology and cancer therapy. Both original articles and systematic reviews are encouraged.
Keywords
reproductive cancers, gynecologic oncology, hormone signaling, DNA repair, PARP inhibitors, immunotherapy, drug resistance, precision medicine
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