Guest Editors
Prof. Ka-Chun Wong, City University of Hong Kong, Hong Kong SAR
Prof. Xiangtao Li, Northeast Normal University, China
Dr. Frederick Kin Hing Phoa, Academia Sinica, Taiwan
Summary
Since the 2010s, the high-throughput sequencing technologies such as Oxford Nanopore sequencing and other third-generation sequencing facilities have revolutionized the molecular biology research field. Such an advancement has propelled a multitude of downstream studies lead to significant impacts on biology, health, and medicine. However, such kind of new data is big, fast, and heterogeneous. It demands a new set of data science and modeling approaches in terms of computational scalability, complexity, and fault-tolerance.
Therefore, we have initiated such a special issue on the data science and modeling in biology, health, and medicine in the hope that researchers can gather their works together in a single special issue for broad and deep impacts on multiple disciplines such as mathematical biology, bioinformatics, computational biology, health informatics, biomedical engineering, cancer informatics, translational medicine, and other related fields.
Keywords
Bioinformatics; Computational Biology; Machine Learning; Data Science; Data Mining; Computational Intelligence; Natural Computing; Genetic Algorithm; Differential Evolution; Evolutionary Computation
Published Papers
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Open Access
ARTICLE
Exploring the Abnormal Brain Regions and Abnormal Functional Connections in SZ by Multiple Hypothesis Testing Techniques
Lan Yang, Shun Qi, Chen Qiao, Yanmei Kang
Computer Modeling in Engineering & Sciences, Vol.125, No.1, pp. 215-237, 2020, DOI:10.32604/cmes.2020.010796
（This article belongs to this Special Issue:
Data Science and Modeling in Biology, Health, and Medicine)
Abstract Schizophrenia (SZ) is one of the most common mental diseases. Its
main characteristics are abnormal social behavior and inability to correctly understand real things. In recent years, the magnetic resonance imaging (MRI) technique has been popularly utilized to study SZ. However, it is still a great challenge
to reveal the essential information contained in the MRI data. In this paper, we
proposed a biomarker selection approach based on the multiple hypothesis testing
techniques to explore the difference between SZ and healthy controls by using
both functional and structural MRI data, in which biomarkers represent both
abnormal brain functional connectivity and…
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Open Access
ARTICLE
Fractional-Order Model for Multi-Drug Antimicrobial Resistance
M. F. Elettreby, Ali S. Alqahtani, E. Ahmed
Computer Modeling in Engineering & Sciences, Vol.124, No.2, pp. 665-682, 2020, DOI:10.32604/cmes.2020.09194
（This article belongs to this Special Issue:
Data Science and Modeling in Biology, Health, and Medicine)
Abstract Drug resistance is one of the most serious phenomena in financial, economic and
medical terms. The present paper proposes and investigates a simple mathematical
fractional-order model for the phenomenon of multi-drug antimicrobial resistance. The
model describes the dynamics of the susceptible and three kinds of infected populations.
The first class of the infected society responds to the first antimicrobial drug but resists
to the second one. The second infected individuals react to the second antimicrobial drug
but resist to the first one. The third class shows resistance to both of the two drugs. We
formulate the model and associate it…
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Open Access
ARTICLE
Effect of Absorption of Patch Antenna Signals on Increasing the Head Temperature
Mohamed Abbas, Ali Algahtani, Amir Kessentini, Hassen Loukil, Muneer Parayangat, Thafasal Ijyas, Abdul Wase Mohammed
Computer Modeling in Engineering & Sciences, Vol.124, No.2, pp. 683-701, 2020, DOI:10.32604/cmes.2020.010304
（This article belongs to this Special Issue:
Data Science and Modeling in Biology, Health, and Medicine)
Abstract Every new generation of antennas is characterized by increased accuracy and faster transmission speeds. However, patch antennas have been known
to damage human health. This type of antenna sends out electromagnetic waves
that increase the temperature of the human head and prevent nerve strands from
functioning properly. This paper examines the effect of the communication
between the patch antenna and the brain on the head’s temperature by developing
a hypothetical multi-input model that achieves more accurate results. These inputs
are an individual’s blood and tissue, and the emission power of the antenna. These
forces depend on the permeability and conductivity…
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Open Access
ARTICLE
A Re-Parametrization-Based Bayesian Differential Analysis Algorithm for Gene Regulatory Networks Modeled with Structural Equation Models
Yan Li, Dayou Liu, Yungang Zhu, Jie Liu
Computer Modeling in Engineering & Sciences, Vol.124, No.1, pp. 303-313, 2020, DOI:10.32604/cmes.2020.09353
（This article belongs to this Special Issue:
Data Science and Modeling in Biology, Health, and Medicine)
Abstract Under different conditions, gene regulatory networks (GRNs) of the
same gene set could be similar but different. The differential analysis of GRNs
under different conditions is important for understanding condition-specific gene
regulatory relationships. In a naive approach, existing GRN inference algorithms
can be used to separately estimate two GRNs under different conditions and identify the differences between them. However, in this way, the similarities between
the pairwise GRNs are not taken into account. Several joint differential analysis
algorithms have been proposed recently, which were proved to outperform the
naive approach apparently. In this paper, we model the GRNs under different…
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Open Access
ARTICLE
Discrete Circular Distributions with Applications to Shared Orthologs of Paired Circular Genomes
Tomoaki Imoto, Grace S. Shieh, Kunio Shimizu
Computer Modeling in Engineering & Sciences, Vol.123, No.3, pp. 1131-1149, 2020, DOI:10.32604/cmes.2020.08466
（This article belongs to this Special Issue:
Data Science and Modeling in Biology, Health, and Medicine)
Abstract For structural comparisons of paired prokaryotic genomes, an important topic in
synthetic and evolutionary biology, the locations of shared orthologous genes (henceforth
orthologs) are observed as binned data. This and other data, e.g., wind directions recorded
at monitoring sites and intensive care unit arrival times on the 24-hour clock, are counted
in binned circular arcs, thus modeling them by discrete circular distributions (DCDs) is
required. We propose a novel method to construct a DCD from a base continuous circular
distribution (CCD). The probability mass function is defined to take the normalized values
of the probability density function at some pre-fixed…
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Open Access
ARTICLE
Growing and Pruning Based Deep Neural Networks Modeling for Effective Parkinson’s Disease Diagnosis
Kemal Akyol
Computer Modeling in Engineering & Sciences, Vol.122, No.2, pp. 619-632, 2020, DOI:10.32604/cmes.2020.07632
（This article belongs to this Special Issue:
Data Science and Modeling in Biology, Health, and Medicine)
Abstract Parkinson’s disease is a serious disease that causes death. Recently, a new
dataset has been introduced on this disease. The aim of this study is to improve the
predictive performance of the model designed for Parkinson’s disease diagnosis. By and
large, original DNN models were designed by using specific or random number of
neurons and layers. This study analyzed the effects of parameters, i.e., neuron number
and activation function on the model performance based on growing and pruning
approach. In other words, this study addressed the optimum hidden layer and neuron
numbers and ideal activation and optimization functions in order…
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