Computational Modeling to Predict Conservative Treatment Outcome for Patients with Plaque Erosion: An OCT-Based Patient-Specific FSI Modeling Study
Yanwen Zhu1,#, Chen Zhao2,#, Yishuo Xu2, Zheyang Wu3, Akiko Maehara4, Liang Wang1, Dirui Zhang2, Ming Zeng2, Rui Lv5, Xiaoya Guo6, Mengde Huang1, Minglong Chen7, Gary S. Mintz4, Dalin Tang1,3,*, Haibo Jia2, Bo Yu2,*
CMES-Computer Modeling in Engineering & Sciences, Vol.144, No.2, pp. 1249-1270, 2025, DOI:10.32604/cmes.2025.067039
- 31 August 2025
Abstract Image-based computational models have been used for vulnerable plaque progression and rupture predictions, and good results have been reported. However, mechanisms and predictions for plaque erosion are under-investigated. Patient-specific fluid-structure interaction (FSI) models based on optical coherence tomography (OCT) follow-up data from patients with plaque erosion and who received conservative antithrombotic treatment (using medication, no stenting) to identify risk factors that could be used to predict the treatment outcome. OCT and angiography data were obtained from 10 patients who received conservative antithrombotic treatment. Five participants had worse outcomes (WOG, stenosis severity ≥ 70% at one-year… More >
Graphic Abstract