Open Access
EDITORIAL
Dalin Tang1,2,*, Zhiyong Li1
CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 109-113, 2018, DOI:10.31614/cmes.2018.04201
（This article belongs to this Special Issue: Innovations and Current Trends in Computational Cardiovascular Modeling: Molecular, Cellular, Tissue and Organ Biomechanics with Clinical Applications)
Abstract This article has no abstract. More >
Open Access
ARTICLE
Long Deng1, Xueying Huang2,3,*, Heng Zuo4, Yuan Zheng2, Chun Yang5, Yunhu Song1, Dalin Tang6
CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 115-125, 2018, DOI: 10.31614/cmes.2018.04076
（This article belongs to this Special Issue: Innovations and Current Trends in Computational Cardiovascular Modeling: Molecular, Cellular, Tissue and Organ Biomechanics with Clinical Applications)
Abstract The mechanisms of systolic anterior motion (SAM) of the mitral valve in hypertrophic obstructive cardiomyopathy (HOCM) remain unclear. To investigate the angle of attack between blood flow and mitral valve leaflets at pre-SAM time point, patient-specific CT-based computational models were constructed for 5 patients receiving septal myectomy surgery to obtain pre- and post-operative 2D vector flow mapping. The comparisons between pre- and post-operative angles of attack based on 2D vector flow mapping of 5 patients were performed. It was found that there was no statistically significant difference between pre- and post-operative angles of attack (61.1±t wao vs. 56.2±56.o, p=0.306, n=5).… More >
Open Access
ARTICLE
Yanxia Wang1, Yu Wang2, Siqi Li3, ur Rehman Aziz3, Shutian Liu1, Kairong Qin2,*
CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 127-147, 2018, DOI: 10.31614/cmes.2018.03985
（This article belongs to this Special Issue: Innovations and Current Trends in Computational Cardiovascular Modeling: Molecular, Cellular, Tissue and Organ Biomechanics with Clinical Applications)
Abstract Assessment of the magnitude and pattern of wall shear stress (WSS) in vivo is the prerequisite for studying the quantitative relationship between exercise-induced WSS and arterial endothelial function. In the previous studies, the calculation of the WSS modulated by exercise training was primarily based upon the rigid tube model, which did not take non-linear effects of vessel elastic deformation into consideration. In this study, with an elastic tube model, we estimated the effect of a bout of 30-minute acute cycling exercise on the WSS and the flow rate in the common carotid artery according to the measured inner diameter, center-line… More >
Open Access
ARTICLE
Sihan Chen1, Bao Li1, Haisheng Yang1, Jianhang Du2, Xiaoling Li2, Youjun Liu1,*
CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 149-162, 2018, DOI: 10.31614/cmes.2018.04133
（This article belongs to this Special Issue: Innovations and Current Trends in Computational Cardiovascular Modeling: Molecular, Cellular, Tissue and Organ Biomechanics with Clinical Applications)
Abstract Enhanced external counterpulsation (EECP) is able to treat myocardial ischemia, which is usually caused by coronary artery stenosis. However, the underlying mechanisms regarding why this technique is effective in treating myocardial ischemia remains unclear and there is no patient-specific counterpulsation mode for different rates of coronary artery stenosis in clinic. This study sought to investigate the hemodynamic effect of varied coronary artery stenosis rates when using EECP and the necessity of adopting targeted counterpulsation mode to consider different rates of coronary artery stenosis. Three 3-dimensional (3D) coronary models with different stenosis rates, including 55% (Model 1), 65% (Model 2), and… More >
Open Access
ARTICLE
Wenxin Wang1,2, Dalin Tang2, Boyan Mao1, Bao Li1, Xi Zhao3, Jian Liu4, Youjun Liu1,*
CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 163-173, 2018, DOI: 10.31614/cmes.2018.04219
（This article belongs to this Special Issue: Innovations and Current Trends in Computational Cardiovascular Modeling: Molecular, Cellular, Tissue and Organ Biomechanics with Clinical Applications)
Abstract Fractional flow reserve (FFR) is the gold standard to identify individual stenosis causing myocardial ischemia in catheter laboratory. The purpose of this study is to present a fast simulation method to estimate FFR value of a coronary artery, which can evaluate the performance of vascular stenosis, based on resistance boundary conditions. A patient-specific 3-dimensional (3D) model of the left coronary system with intermediate diameter stenosis was reconstructed based on the CTA images. The resistance boundary conditions used to simulate the coronary microcirculation were computed based on anatomical reconstruction of coronary 3D model. This study was performed by coupling the 3D… More >
Open Access
ARTICLE
Lizhong Mu1, *, Qingzhuo Chi1, Changjin Ji2, Ying He1, Ge Gao3
CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 175-197, 2018, DOI:10.31614/cmes.2018.04191
（This article belongs to this Special Issue: Innovations and Current Trends in Computational Cardiovascular Modeling: Molecular, Cellular, Tissue and Organ Biomechanics with Clinical Applications)
Abstract
To improve aneurysm treatment, this study examined the influence of clip locations on hemodynamic factors in patient-specific anterior communicating artery (ACoA) aneurysms with different aneurysmal angle. We proposed a simplified classification of ACoA aneurysms using aneurysmal angle, defined by the angle of pivot of the aneurysmal dome and the virtual two-dimensional plane created by both proximal A2 segments of anterior cerebral artery (ACA). ACoA aneurysms with three different aneurysmal angles, which are 15°, 80° and 120°, were analyzed in our study. In this work, we obtained hemodynamics before and after clipping surgery with three clip locations based on clinical clipping… More >
Open Access
ARTICLE
Guangliang Pan1, Yu Chang1,*, Mingrui Fu1
CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 199-213, 2018, DOI: 10.31614/cmes.2018.04080
（This article belongs to this Special Issue: Innovations and Current Trends in Computational Cardiovascular Modeling: Molecular, Cellular, Tissue and Organ Biomechanics with Clinical Applications)
Abstract Patients with extracorporeal membrane oxygenation still suffer from high rates of complication that linked to the flow field within the blood pump. So it is essential to optimise the geometry of the pump. The specification of shroud design is arguably the necessary design parameter in the centrifugal pump. However, the hemodynamic performances of the different shroud designs have not been studied extensively. In this study, ten different shroud designs were made and divided into two groups as the different covering locations (A: Covering the blade leading edge, B: Covering the blade trailing edge). In every group, six shroud designs with… More >
Open Access
ARTICLE
Xudong Liu1, Yunhan Cai1, Bing Jia2, Shengzhang Wang1,*, Guanghong Ding1
CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 215-228, 2018, DOI: 10.31614/cmes.2018.04158
（This article belongs to this Special Issue: Innovations and Current Trends in Computational Cardiovascular Modeling: Molecular, Cellular, Tissue and Organ Biomechanics with Clinical Applications)
Abstract Our study evaluated the hemodynamic performance of an axial flow blood pump surgically implanted in idealized total cavopulmonary connection (TCPC) models. This blood pump was designed to augment pressure from the inferior vena cava (IVC) to the pulmonary circulation. Two Fontan procedures with single and bilateral superior vena cava (SVC) were compared to fit the mechanical supported TCPC physiologies. Computational fluid dynamics (CFD) analyses of two Pump-TCPC models were performed in the analyses. Pressure-flow characteristics, energy efficiency, fluid streamlines, hemolysis and thrombosis analyses were implemented. Numerical simulations indicate that the pump produces pressure generations of 1 mm to 24 mm… More >
Open Access
ARTICLE
Zhou Zhao1, Boyan Mao2, Youjun Liu2, Haisheng Yang2, Yu Chen1,*
CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 229-245, 2018, DOI: 10.31614/cmes.2018.04192
（This article belongs to this Special Issue: Innovations and Current Trends in Computational Cardiovascular Modeling: Molecular, Cellular, Tissue and Organ Biomechanics with Clinical Applications)
Abstract In coronary artery bypass grafting (CABG), graft’s poor instant patency may lead to an abnormal hemodynamic environment in anastomosis, which could further cause graft failure after the surgery. This paper investigates the graft hemodynamics with different instant patency, and explores its effect on graft postoperative efficiency. Six CABG 0D/3D coupling multi-scale models which used left internal mammary artery (LIMA) and saphenous vein (SVG) as grafts were constructed. Different types of grafts were examined in the models, including normal grafts, grafts with competitive flow and grafts with anastomotic stenosis. Simulation results indicated that comparing with SVG grafts, there was a greater… More >
Open Access
ARTICLE
Qi Zhang1, Bin Gao1, Yue Shi1, Chang Yu1,*
CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 247-262, 2018, DOI: 10.31614/cmes.2018.04082
（This article belongs to this Special Issue: Innovations and Current Trends in Computational Cardiovascular Modeling: Molecular, Cellular, Tissue and Organ Biomechanics with Clinical Applications)
Abstract Although pulsatile ECMO, as novel kinds of ECMO, has been attracted more and more attention, the differences of the hemodynamic effects of the pulsatile ECMO on the aorta, the cerebral perfusion, and left ventricular work were still under-investigated. The aim of this study was to clarify the hemodynamic differences of the cardiovascular system between the pulsatile and non-pulsatile VA ECMO. In this study, three ECMO support modes, named as “constant flow mode”, “co-pulse mode” and “counter pulse mode”, were designed. The computational fluid dynamics (CFD) study was carried out. The distribution of the oxygenated blood, the blood velocity vector, the… More >
Open Access
ARTICLE
Ning Li1, 2, 3, Xiao Zhang1, 2, Peiwen Li1, 2, Hao Yang1, 2, Chunfang Tong1, 2, Shouqin Lü1, 2, Yan Zhang1, 2, Zhiyi Ye3, Jun Pan3, *, Mian Long1, 2, *
CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 263-279, 2018, DOI:10.31614/cmes.2018.04079
（This article belongs to this Special Issue: Innovations and Current Trends in Computational Cardiovascular Modeling: Molecular, Cellular, Tissue and Organ Biomechanics with Clinical Applications)
Abstract Neutrophil (PMN) accumulation on liver sinusoidal endothelial cells (LSECs) is crucial to pathogen clearance and tissue damage in the liver sinusoids and controlled by a series of adhesion molecules expressed on the surface of PMNs and LSECs. The role of lymphocyte function-associated antigen-1 (LFA-1) and macrophage-1 antigen (Mac-1) in this process is still contentious. Here we compared the dynamic force spectra of the binding of β2 integrin to intercellular adhesion molecule-1 (ICAM-1) on LSECs using atomic force microscopy (AFM) and performed free and steered molecular dynamics (MD) simulations to analyze their structural bases of LFA-1- or Mac-1-I-domain and ICAM-1-D1 or… More >
Open Access
ARTICLE
Xinyue Liu1, Yunqiao Liu1, Xiaobo Gong1,*, Huaxiong Huang2
CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 281-300, 2018, DOI: 10.31614/cmes.2018.04989
（This article belongs to this Special Issue: Innovations and Current Trends in Computational Cardiovascular Modeling: Molecular, Cellular, Tissue and Organ Biomechanics with Clinical Applications)
Abstract In this work, a three-dimensional axisymmetric model with nanoparticle, receptor-ligand bonds and cell membrane as a system was used to study the quasi-static receptor-mediated endocytosis process of spherical nanoparticles in drug delivery. The minimization of the system energy function was carried out numerically, and the deformations of nanoparticle, receptor-ligand bonds and cell membrane were predicted. Results show that passive endocytosis may fail due to the rupture of receptor-ligand bonds during the wrapping process, and the size and rigidity of nanoparticles affect the total deformation energy and the terminal wrapping stage. Our results suggest that, in addition to the energy requirement,… More >
Open Access
ARTICLE
Jing Zhang1,2,3, Xiuqing Qian1,2, Haixia Zhang1,2, Zhicheng Liu1,2,*
CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 301-314, 2018, DOI: 10.31614/cmes.2018.04239
（This article belongs to this Special Issue: Innovations and Current Trends in Computational Cardiovascular Modeling: Molecular, Cellular, Tissue and Organ Biomechanics with Clinical Applications)
Abstract Elevated intraocular pressure appears to have a broader impact on increased resistance to aqueous humor outflow through the conventional aqueous outflow system (AOS). However, there is still no consensus about exact location of the increased outflow resistance of aqueous humor, and the mechanism is not perfect. In addition, it is difficult to accurately obtain hydrodynamic parameters of aqueous humor within the trabecular meshwork outflow pathways based on the current technology. In this paper, a two-way fluid-structure interaction simulation was performed to study the pressure difference and velocity in the superficial trabecular meshwork, juxtacanalicular meshwork (JCM) and Schlemm’s canal in response… More >
Open Access
ARTICLE
Shen Yu1, Jizhe Wang2,*, Yan Guo2,*, Xiuzhen Sun2, Shuang Shen3
CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 315-322, 2018, DOI: 10.31614/cmes.2018.04028
（This article belongs to this Special Issue: Innovations and Current Trends in Computational Cardiovascular Modeling: Molecular, Cellular, Tissue and Organ Biomechanics with Clinical Applications)
Abstract A three-dimensional numerical model of the membranous labyrinth of the semicircular canal of the inner ear was established to investigate the effects of canalithiasis of BPPV on the balance function of the inner ear. The movement of otolith particles in the membranous labyrinth was simulated when a person turns his head to a specific position. The effects of otolith movements on the balance function of the inner ear were simulated for different numbers, diameters, and initial positions of otoliths. The simulation results show that the otolith diameter affects the movement duration of otoliths in the membranous labyrinth. The number and… More >
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