Special Issues
Table of Content

Novel Strategies in the Diagnosis, Prediction, Monitoring, and Treatment of Brain Tumors

Submission Deadline: 31 August 2025 (closed) View: 374 Submit to Journal

Guest Editors

Prof. Maria Caffo

Email: mariella.caffo@unime.it

Affiliation: Unit of Neurosurgery, Department of Biomorphology and Dental Sciences, and Morphofunctional Imaging, University of Messina, AOU “G. Martino”, Messina, Italy

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Research Interests: glioblastoma multiforme (GBM), astrocytoma, medulloblastoma, neuroradiology, magnetic resonance, glioma, molecular oncology, meningioma,neurosurgery


Summary

Brain tumors remain one of the most challenging areas in oncology, both in terms of understanding the underlying mechanisms and improving clinical outcomes. Despite significant advancements, the diagnosis, prediction, monitoring, and treatment of brain tumors continue to present complex obstacles. This special issue seeks to explore novel and cutting-edge strategies that have the potential to significantly impact the clinical management of brain tumors.

 

We invite original research articles, reviews, and clinical studies that address innovative approaches in the following areas:

 

Early Detection and Diagnosis: New biomarkers, imaging technologies, and diagnostic techniques that enhance early identification and accurate diagnosis of brain tumors.


Prediction and Prognostication: Novel methodologies in predicting tumor behavior, patient outcomes, and therapeutic responses through molecular profiling and computational models.

 

Monitoring Tumor Progression: Innovative strategies for monitoring tumor evolution, treatment efficacy, and recurrence, with an emphasis on non-invasive technologies and biomarkers.

 

Targeted Therapies and Immunotherapy: Advancements in targeted therapies, immunotherapies, and precision medicine that offer hope for more effective treatments with fewer side effects.

 

Regenerative and Nanomedicine Approaches: Emerging fields such as stem cell therapy, nanotechnology, and gene editing technologies, which hold promise in the treatment of brain tumors.

 

We aim to highlight breakthroughs and interdisciplinary efforts that pave the way for novel clinical practices and significantly improve the survival and quality of life for patients with brain tumors. This special issue will provide an essential platform for researchers, clinicians, and healthcare professionals working at the forefront of neuro-oncology.


Keywords

Brain Tumors, Early Detection, Molecular Profiling, Targeted Therapy, Immunotherapy, Tumor Monitoring

Published Papers


  • Open Access

    REVIEW

    Epigenomic and Metabolic Interplay in the Development of Metastatic Brain Tumors

    Vishal Rastogi, Deepak Verma, Saurabh Verma, Prakash Haloi, Shruti Kapoor, Havagiray R. Chitme, Nethaji Muniraj, Priyanka Saroj
    Oncology Research, DOI:10.32604/or.2026.072620
    (This article belongs to the Special Issue: Novel Strategies in the Diagnosis, Prediction, Monitoring, and Treatment of Brain Tumors)
    Abstract Metastatic brain tumors undergo profound metabolic–epigenetic reprogramming driven by the unique constraints of the brain microenvironment. Hypoxia-inducible factor-1α (HIF1α) enhances glycolytic flux, lactate accumulation, and histone lactylation, collectively supporting metastatic colonization and immune evasion. Key metabolites including acetyl-CoA, S-adenosylmethionine (SAM), α-ketoglutarate (α-KG), fumarate, and 2-hydroxyglutarate (2-HG)—directly modify chromatin states by regulating histone acetyltransferases, DNA/histone methyltransferases, and α-KG dependent dioxygenases such as Ten-Eleven Translocation (TET) enzymes and lysine demethylases (KDMs). These metabolic shifts result in aberrant DNA methylation, histone lysine residue at position 27 on Histone H3 (H3K27) trimethylation, and depletion of 5-hydroxymethylcytosine (5hmC), all of… More >

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