Guest Editors
Prof. Constantin Caruntu
Email: costin.caruntu@gmail.com, constantin.caruntu@umfcd.ro
Affiliation: Department of Physiology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, 050474, Romania
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Research Interests: dermato-oncology, immuno-oncology, molecular oncology, translational cancer research, advanced imaging in oncology, inflammation and cancer
Assoc. Prof. Anca Zgura
Email: medicanca@gmail.com, anca.zgura@umfcd.ro
Affiliation: Department of Oncology-Radiotherapy, "Carol Davila" University of Medicine and Pharmacy, Bucharest, 050474, Romania
Homepage:
Research Interests: immuno-oncology, breast cancer research, thoracic and genitourinary malignancies, gastrointestinal cancers, gynecologic oncology, cancer and comorbidities, translational and clinical research, oncology in the COVID-19 era, precision medicine
Summary
Immunotherapy has transformed the landscape of cancer treatment, offering durable benefits for patients across a wide range of malignancies. Despite these advances, therapeutic responses remain heterogeneous, and many patients either fail to respond or eventually develop resistance. A growing body of evidence highlights the tumor microenvironment (TME) as a central determinant of immune activation, suppression, and escape, shaping both disease progression and treatment outcomes. Understanding the interplay between immunotherapy and the TME is therefore critical to overcoming resistance mechanisms and optimizing clinical efficacy.
This Special Issue seeks to bring together innovative research and comprehensive reviews that span the spectrum from mechanistic insights to translational and clinical applications. We invite contributions exploring novel immunotherapeutic strategies, the molecular and cellular dynamics of the TME, biomarker discovery, and predictive approaches for patient stratification. Studies addressing preclinical models, combination therapies, and clinical trials that bridge laboratory findings with real-world practice are especially encouraged. By fostering an integrative view of immunotherapy and tumor microenvironmental research, this Special Issue aims to highlight emerging opportunities and chart future directions for improving outcomes in oncology.
Keywords
immunotherapy, tumor microenvironment, immune evasion, resistance mechanisms, cancer progression, translational research, biomarker discovery, patient stratification, combination therapy, clinical trials, tumor-immune interactions
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