Guest Editors
Prof. Dr. Leonardo Oliveira Reis
Email: reisleo.l@gmail.com
Affiliation: UroScience, School of Medical Sciences, University of Campinas, Campinas, 13083-887, Brazil.
Homepage:
Research Interests: genitourinary cancer, tumor immunology
Summary
The Special Issue aims to gather high-impact, interdisciplinary research at the forefront of genitourinary (GU) oncology and tumor immunology. Genitourinary cancers, including malignancies of the prostate, bladder, kidney, testis, and other components of the urinary and reproductive systems, pose a substantial global health burden. Despite significant advances in diagnostics and therapeutics, major challenges persist in early detection, treatment resistance, disease recurrence, and patient stratification.
This Special Issue will serve as a platform to showcase innovative translational and clinical research that integrates insights from oncology, immunology, molecular biology, bioinformatics, and biomedical engineering. It will emphasize the evolving understanding of tumor-immune interactions, novel immunotherapeutic approaches, biomarker discovery, and precision medicine strategies tailored to GU malignancies.
Keywords
·Tumor microenvironment and immune modulation in genitourinary cancers
·Checkpoint inhibitors, CAR-T cell therapy, and other immunotherapies
·Tumor antigen discovery and neoantigen prediction in GU tumors
·Molecular profiling and genomic alterations in GU cancers
·Biomarkers for response and resistance to immunotherapy
·Immuno-oncology clinical trials in bladder, prostate, and renal cancers
·Combination therapies integrating immunotherapy with chemotherapy, targeted therapy, or radiation
·Liquid biopsies, circulating tumor DNA, and non-invasive diagnostics
·Artificial intelligence and machine learning applications in immuno-oncology
·Comparative oncology and insights from animal models of GU cancer
·Health disparities, ethics, and personalized approaches in GU immuno-oncology
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