Special Issues
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Advances in Pediatric and Adolescent Oncology: From Bench to Bedside

Submission Deadline: 30 August 2026 View: 340 Submit to Special Issue

Guest Editor(s)

Prof. Antonio Ruggiero

Email: antonio.ruggiero@unicatt.it

Affiliation: Pediatric Oncology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica Sacro Cuore, 00168 Rome, Italy

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Research Interests: Pediatric oncology, childhood cancer therapeutics, late effects of cancer treatment, adolescent and young adult oncology, translational cancer research


Dr. Giorgio Attinà

Email: giorgio.attina@policlinicogemelli.it

Affiliation: Pediatric Oncology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica Sacro Cuore, 00168 Rome, Italy

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Research Interests: Pediatric oncology, supportive care in childhood cancer, cardio-oncology, long-term survivorship


Summary

Pediatric and adolescent cancers represent a unique challenge in oncology, requiring specialized approaches that differ fundamentally from adult malignancies. Despite significant advances in survival rates over the past decades, childhood cancer remains a leading cause of disease-related mortality in children and adolescents. This special issue aims to provide a comprehensive overview of current advances and emerging trends in pediatric oncology, encompassing novel therapeutic strategies, precision medicine approaches, immunotherapy applications, and supportive care innovations.


The scope includes both common and rare pediatric malignancies, including leukemias, brain tumors, solid tumors, and sarcomas affecting children and adolescents from infancy through young adulthood. We welcome original research articles, systematic reviews, and clinical perspectives addressing molecular diagnostics, targeted therapies, , radiotherapy innovations, surgical advances, and management of treatment-related complications. Special emphasis will be placed on translational research bridging laboratory discoveries with clinical applications, quality of life considerations, long-term survivorship issues, and late effects monitoring. This special issue seeks to foster collaboration among pediatric oncologists, researchers, surgeons, radiation oncologists, and supportive care specialists to advance the field and improve outcomes for young cancer patients worldwide.


Keywords

Pediatric oncology, childhood cancer, adolescent malignancies, pediatric leukemia, pediatric brain tumors, neuroblastoma, sarcomas, precision medicine, immunotherapy, targeted therapy, supportive care, survivorship, late effects, quality of life

Published Papers


  • Open Access

    ARTICLE

    Germline Predisposition in Pediatric Central Nervous System Tumors: Insights from a Multigene Panel Study

    Meerim Park, Seungman Park, Ensel Oh, Jongmun Choi, Mi Mi Kwon, Seog-Yun Park, Jun Ah Lee, Hyeon Jin Park
    Oncology Research, DOI:10.32604/or.2026.079120
    (This article belongs to the Special Issue: Advances in Pediatric and Adolescent Oncology: From Bench to Bedside)
    Abstract Objectives: Germline variants in cancer predisposition genes have been increasingly recognized in pediatric cancers. However, their spectrum in East Asian children with central nervous system (CNS) tumors remains insufficiently defined. This study investigated the prevalence and clinical significance of pathogenic or likely pathogenic (P/LP) germline mutations in Korean children, adolescents, and young adults (AYAs) with CNS tumors. Methods: We performed targeted next-generation sequencing of 358 cancer-associated genes using peripheral blood DNA from 108 patients. Germline variants were classified according to ACMG/AMP guidelines and curated using ClinVar and relevant literature. Results: Among 108 patients, 17 (15.7%) carried P/LP… More >

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