Guest Editors
Prof. Frank Traub
E-mail: Frank.Traub@unimedizin-mainz.de
Affiliation: Department of Orthopaedics and Traumatology, University Medical Center of The Johannes Gutenberg University Mainz, D-55131 Mainz, Germany.
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Research Interests: Osteosarcoma, Sarcoma, Ewing's Sarcoma, Chondrosarcoma, Oncologic Orthopedia, Cancer, Cancer Biology
Summary
Sarcomas are rare and highly heterogeneous cancers, presenting significant challenges in diagnosis and treatment. Despite progress in individualized, multimodal approaches combining surgery, chemotherapy, and radiotherapy, more research is essential to refine these treatments and improve outcomes.
Diagnosis: Initial imaging and biopsy are critical, but more evidence is needed to enhance diagnostic accuracy and better differentiate between benign and malignant tumors. A deeper understanding of tumor subtypes and biological behaviors would aid in treatment planning.
Treatment Modalities: While limb-salvage surgery has replaced amputation for many soft tissue sarcomas, the optimal timing and necessity of radiotherapy—preoperative vs. postoperative—remain unclear. Further studies are needed, especially to determine whether radiotherapy can be safely omitted in low-risk cases.
Chemotherapy: The role of preoperative chemotherapy, particularly in conjunction with isolated limb perfusion, requires more evidence to establish its effectiveness in function preservation.
Retroperitoneal Sarcomas: Aggressive surgery is becoming standard, but additional research is critical to clarify the role of preoperative radiotherapy and chemotherapy in reducing the high risk of local recurrence.
Overall, a stronger evidence base is vital to advance sarcoma treatment, improve survival, and reduce recurrence rates. Continued research is crucial for optimizing treatment strategies and improving patient outcomes.
Keywords
Bone sarcoma, Soft tissue sarcoma, Sarcoma treatment, Multimodal therapy, Preoperative radiotherapy, Chemotherapy in sarcomas, Limb-salvage surgery, Retroperitoneal sarcoma treatment
Published Papers
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