Guest Editor(s)
Prof. Joanna Zawitkowska
Email: joanna.zawitkowska@umlub.edu.pl
Affiliation: Department of Pediatric Hematology, Oncology and Transplantation, Medical University of Lublin, Lublin, Poland
Homepage:
Research Interests: childhood leukemias, anticancer therapy
Assoc. Prof. Małgorzata Mitura-Lesiuk
Email: malgorzata.mitura-lesiuk@umlub.edu.pl
Affiliation: Department of Pediatric Hematology, Oncology and Transplantology, Medical University of Lublin, Lublin, Poland
Homepage:
Research Interests: pediatric oncology, acute lymphoblastic leukemia
Dr. Maciej Dubaj
Email: maciej.dubaj99@gmail.com
Affiliation: Department of Pediatric Hematology, Oncology and Transplantology, Medical University of Lublin, Lublin, Poland
Homepage:
Research Interests: pediatric oncology, miRNAs, acute lymphoblastic leukemia, antibody therapy
Summary
The success of modern pediatric oncology has led to survival rates exceeding 80% in many malignancies. Classic chemotherapy remains an important element, but there are opportunities to further increase cure rates through the use of targeted therapies and immunotherapy. This special issue focuses on the molecular mechanisms underlying childhood cancer development and treatment response.
Topics covered include the identification of potential cancer targets and exploration of novel molecular mechanisms of tumor initiation and metastasis in pediatric malignancies; the development of novel small molecules and targeted therapies; mechanisms of drug sensitivity and cellular resistance; biomarkers of response and/or resistance; pharmacogenetics and pharmacogenomics in pediatric oncology; personalized medicine approaches; the role of cancer stem cells; immunotherapy and clinical immunology; gene therapy; and non-coding RNAs as regulators of cellular gene expression.
Together, these articles aim to advance our understanding of childhood cancer biology and support the development of more effective, mechanism-driven therapeutic strategies.
Keywords
pediatric oncology, targeted therapies, immunotherapy, molecular mechanisms, personalized medicine
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