Special Issues
Table of Content

Advances in Genitourinary Cancer

Submission Deadline: 28 February 2025 (closed) View: 586 Submit to Journal

Guest Editor(s)

Leonardo Oliveira Reis, Department of Urology, Pontifical Catholic University of Campinas, São Paulo, 13086-900, Brazil. E-mail: reisleo.l@gmail.com

Mario I. Fernández, Department of Urology, Clínica Alemana de Santiago, Santiago, 7591046, Chile. E-mail: mariofernandez@udd.cl

Jose Ignacio Nolazco, Brigham and Women's Hospital, Harvard Medical School, Boston, 02115, USA. E-mail: JNolazco@bwh.harvard.edu


Summary

Urologic oncology is a rapidly evolving field, offering new perspectives and therapeutic avenues. Advances in modern approaches to diagnosing and treating genitourinary tumors enable strategic and tailored treatments that provide optimal oncological, functional, and quality of life outcomes. More precise diagnostic techniques help avoid late and over-diagnosis, while individualized therapies prevent over-treatment. New therapies have been developed based on improved prognostication capacity through the development of new biological predictors and strategies involving theranostic (combining therapeutic and diagnostic capabilities to both locate and treat cancer with targeted therapy) and immuno-oncological (supporting the natural immune response) knowledges. Liquid biopsies, from biological fluids, holds promise for non-invasive cancer monitoring and early detection of recurrence. Research into patient’s unique genetic profile provides insights into the aggressiveness of genitourinary cancer, helping to tailor treatment plans. Generative artificial intelligence and progressively autonomous robotic platforms grows in direction of improvement and systematization of minimally invasive surgical techniques. Ongoing research efforts aim to refine these methodologies further, enhancing outcomes for patients facing these complex cancers.


Keywords

Urologic Oncology, Genitourinary Oncology

Published Papers


  • Open Access

    REVIEW

    First-Line Treatment Strategies in IMDC Favourable-Risk Metastatic Clear Cell Renal Cell Carcinoma

    Alejandro Valdés, Jaime González-Montero, Carlos Rojas, Mauricio Burotto
    Oncology Research, Vol.34, No.8, 2026, DOI:10.32604/or.2026.077711
    (This article belongs to the Special Issue: Advances in Genitourinary Cancer)
    Abstract Immune checkpoint inhibitors (ICIs) combined with vascular endothelial growth factor tyrosine kinase inhibitors (VEGF-TKIs) have transformed the treatment landscape of advanced clear cell renal cell carcinoma (ccRCC). Current guidelines favour ICI plus VEGF-TKI (IO+TKI) combinations for favourable-risk disease (International Metastatic RCC Database Consortium [IMDC] score 0) based on improved objective response rates and progression-free survival. However, no IO+TKI combination has demonstrated a statistically significant overall survival (OS) benefit in this subgroup. A pooled analysis of four pivotal phase III trials (n = 839 favourable-risk patients) revealed no OS advantage for IO+TKI versus sunitinib monotherapy (hazard… More >

    Graphic Abstract

    First-Line Treatment Strategies in IMDC Favourable-Risk Metastatic Clear Cell Renal Cell Carcinoma

  • Open Access

    ARTICLE

    Immunohistochemical Expression of Novel Therapeutic Targets in Squamous Cell Carcinoma of the Bladder

    Lisa J. Frey, Nina Lache, Nikita D. Fischer, Niklas Rölz, Lisa Frey, Maximilian Haack, Gregor Duwe, Stefan Porubsky, Axel Haferkamp, Daniel-C. Wagner, Maximilian P. Brandt
    Oncology Research, Vol.34, No.8, 2026, DOI:10.32604/or.2026.078954
    (This article belongs to the Special Issue: Advances in Genitourinary Cancer)
    Abstract Objectives: Squamous cell carcinoma (SCC) of the bladder is an aggressive histologic subtype with distinct clinical behavior and limited treatment options after platinum-based chemotherapy. This study aimed to evaluate potential therapeutic targets in bladder SCC. Methods: A retrospective cohort of 790 patients who underwent radical cystectomy for bladder cancer between 2011 and 2021 was screened to identify cases with histologically confirmed SCC. All SCC cases in the pathology department from 2003 to 2011 were also reviewed. Clinical and pathological data from 54 patients were analyzed. A tissue microarray (TMA) was constructed, and immunohistochemical (IHC) analyses… More >

  • Open Access

    ARTICLE

    Intradermal priming to intravesical Bacillus Calmette-Guérin in non-muscle invasive bladder cancer: A translational research and phase I clinical trial

    LUCIANA SABOYA, KEINI BUOSI, TIAGO SILVA, ELAINE CANDIDO, JOSIANE MORARI, LICIO A. VELLOSO, SHAHROKH F. SHARIAT, MARCUS V. SADI, LEONARDO O. REIS
    Oncology Research, Vol.33, No.6, pp. 1495-1503, 2025, DOI:10.32604/or.2025.061812
    (This article belongs to the Special Issue: Advances in Genitourinary Cancer)
    Abstract Objective: To determine the safety and the role of modulating cytokines and proteases in the immune response to intravesical Bacillus Calmette-Guérin (BCG) when primed with systemic intradermal BCG. Methods: Phase 1 and mechanistic longitudinal, prospective, single-blind randomized study (NCT04806178). Twenty-one non-muscle invasive urothelial bladder cancer patients undergoing intravesical adjuvant BCG after transurethral resection of bladder tumor (TURBT) in a teaching hospital between September 2021 and April 2023 were randomized to 0.1 mL of intradermal BCG vaccine or placebo (0.9% saline) administered 15 days before the start of intravesical BCG therapy. Blood samples were evaluated mechanistically… More >

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