Special Issues
Table of Content

Advances in Genitourinary Cancer

Submission Deadline: 28 February 2025 (closed) View: 529 Submit to Journal

Guest Editor(s)

Leonardo Oliveira Reis, Department of Urology, Pontifical Catholic University of Campinas, São Paulo, 13086-900, Brazil. E-mail: reisleo.l@gmail.com

Mario I. Fernández, Department of Urology, Clínica Alemana de Santiago, Santiago, 7591046, Chile. E-mail: mariofernandez@udd.cl

Jose Ignacio Nolazco, Brigham and Women's Hospital, Harvard Medical School, Boston, 02115, USA. E-mail: JNolazco@bwh.harvard.edu


Summary

Urologic oncology is a rapidly evolving field, offering new perspectives and therapeutic avenues. Advances in modern approaches to diagnosing and treating genitourinary tumors enable strategic and tailored treatments that provide optimal oncological, functional, and quality of life outcomes. More precise diagnostic techniques help avoid late and over-diagnosis, while individualized therapies prevent over-treatment. New therapies have been developed based on improved prognostication capacity through the development of new biological predictors and strategies involving theranostic (combining therapeutic and diagnostic capabilities to both locate and treat cancer with targeted therapy) and immuno-oncological (supporting the natural immune response) knowledges. Liquid biopsies, from biological fluids, holds promise for non-invasive cancer monitoring and early detection of recurrence. Research into patient’s unique genetic profile provides insights into the aggressiveness of genitourinary cancer, helping to tailor treatment plans. Generative artificial intelligence and progressively autonomous robotic platforms grows in direction of improvement and systematization of minimally invasive surgical techniques. Ongoing research efforts aim to refine these methodologies further, enhancing outcomes for patients facing these complex cancers.


Keywords

Urologic Oncology, Genitourinary Oncology

Published Papers


  • Open Access

    ARTICLE

    Intradermal priming to intravesical Bacillus Calmette-Guérin in non-muscle invasive bladder cancer: A translational research and phase I clinical trial

    LUCIANA SABOYA, KEINI BUOSI, TIAGO SILVA, ELAINE CANDIDO, JOSIANE MORARI, LICIO A. VELLOSO, SHAHROKH F. SHARIAT, MARCUS V. SADI, LEONARDO O. REIS
    Oncology Research, Vol.33, No.6, pp. 1495-1503, 2025, DOI:10.32604/or.2025.061812
    (This article belongs to the Special Issue: Advances in Genitourinary Cancer)
    Abstract Objective: To determine the safety and the role of modulating cytokines and proteases in the immune response to intravesical Bacillus Calmette-Guérin (BCG) when primed with systemic intradermal BCG. Methods: Phase 1 and mechanistic longitudinal, prospective, single-blind randomized study (NCT04806178). Twenty-one non-muscle invasive urothelial bladder cancer patients undergoing intravesical adjuvant BCG after transurethral resection of bladder tumor (TURBT) in a teaching hospital between September 2021 and April 2023 were randomized to 0.1 mL of intradermal BCG vaccine or placebo (0.9% saline) administered 15 days before the start of intravesical BCG therapy. Blood samples were evaluated mechanistically… More >

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