Guest Editors
Dr. Paolo Coghi
Email: coghips@must.edu.mo
Affiliation: School of Pharmacy, Macau University of Science and Technology, Macau, 999078, China
Homepage:
Research Interests: cancer, infectious disease, medicinal chemistry

Summary
Cancer drug resistance remains a major challenge, limiting the effectiveness of conventional therapies and leading to disease recurrence. This special issue aims to explore innovative strategies to overcome resistance mechanisms, including targeted therapies, combination treatments, and the role of natural compounds as potential adjuvants.
We invite original research and review articles on topics such as:
· Molecular mechanisms underlying drug resistance in cancer.
· Novel therapeutic approaches, including gene editing, nanomedicine, and immunotherapy.
· Synergistic effects or chemical modification of natural compounds with existing anticancer drugs.
· Preclinical and clinical studies evaluating natural products in overcoming resistance.
This issue will serve as a platform for researchers to present cutting-edge findings, fostering collaboration toward more effective and sustainable cancer treatments.
Keywords
Cancer, natural product, immunotherapy, medicinal chemistry