Guest Editor(s)
Dr. Bufu Tang
Email: tangbufu@zju.edu.cn
Affiliation: Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, China
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Research Interests: tumor microenvironment, multi-omics profiling of malignancies, ferroptosis and tumor immunotherapy, translational research for minimally invasive tumor treatment, biochemistry and molecular biology, pharmacology of anti-cancer drugs
Prof. Zhiyong Xu
Email: xuzy3371@zjcc.org.cn
Affiliation: Breast Cancer Center, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine, Chinese Academy of Sciences, Hangzhou, China
Homepage:
Research Interests: tumor microenvironment, tumor endothelial cell heterogeneity, anti-tumor immunity and immunotherapy resistance
Summary
The tumor microenvironment (TME) is a core determinant of tumor progression, therapeutic resistance, and immunotherapy efficacy, yet its inherent cellular and molecular heterogeneity remains a fundamental challenge in precision oncology. The rapid development of multi-omics approaches—including single-cell and spatial transcriptomics, proteomics, metabolomics, and epigenomics—has revolutionized our ability to map TME complexity at unprecedented resolution, revealing novel cell subsets, signaling circuits, and molecular signatures. Nevertheless, a prominent translational gap remains: the vast majority of candidate biomarkers and therapeutic targets derived from omics surveys lack systematic functional validation through in vitro and in vivo experimental models, leaving most discoveries at descriptive levels without clinical translatability.
This special issue is dedicated to advancing TME research by integrating multi-omics profiling with rigorous experimental validation. We invite original investigations and authoritative reviews that explore immune-stromal crosstalk, regulated cell death pathways, metabolic reprogramming, therapeutic resistance mechanisms, and interventional therapy-induced TME remodeling. This collection will foster the translation of multi-omics discoveries into mechanistic insights and actionable therapeutic strategies, offering new perspectives for overcoming tumor heterogeneity and improving clinical outcomes in oncology.
Graphic Abstract
Keywords
tumor microenvironment, translational oncology, multi-omics analysis, immune microenvironment, cell death, metabolic reprogramming, therapeutic resistance
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