Special Issues
Table of Content

Advancements in Hepatocellular Carcinoma Treatment

Submission Deadline: 30 June 2026 View: 276 Submit to Special Issue

Guest Editors

Prof. Hooman Yarmohammadi

Email: yarmohah@mskcc.org

Affiliation: Department of Radiology, Memorial Sloan Kettering Cancer Center, 10065, New York, United States

Homepage:

Research Interests: Liver cancer and conditions Liver metastases Gallbladder cancer Pancreatic cancer and conditions Lung cancer


Summary

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide, with rising incidence rates linked to liver diseases such as cirrhosis and viral hepatitis. Despite advances in diagnosis and management, effective treatment options remain limited, and the prognosis for advanced HCC patients is still poor.


This special issue aims to highlight recent developments in the treatment of HCC, including novel therapeutic agents, combination therapies, and personalized medicine approaches. Topics of interest include targeted therapies, immune checkpoint inhibitors, gene therapy, and the role of biomarkers in predicting treatment responses. Additionally, the issue will explore new perspectives on surgical, radiological, and interventional treatments. We invite original research, clinical trials, and reviews that offer insights into the future directions of HCC therapy, with the goal of improving patient outcomes and quality of life.


Keywords

Hepatocellular carcinoma (HCC), Targeted therapies, Immune checkpoint inhibitors, Personalized medicine, Liver cancer treatment, Clinical trials

Published Papers


  • Open Access

    REVIEW

    Current and Future Landscape of Hepatocellular Carcinoma Treatment

    Shadi Zerehpoosh, Yasuhito Tanaka, Said A. Al-Busafi, Gulnara Aghayeva, Samir Rouabhia, Qiuwei Pan, Mohammed Eslam
    Oncology Research, DOI:10.32604/or.2026.076937
    (This article belongs to the Special Issue: Advancements in Hepatocellular Carcinoma Treatment)
    Abstract Hepatocellular carcinoma (HCC) represents a critical global health challenge, standing as a leading cause of cancer mortality with a significant and projected increasing incidence worldwide. A primary hurdle in HCC management is late diagnosis, often attributable to the absence of early symptoms. Despite considerable advancements in therapeutic strategies over the past decade, including immune checkpoint inhibitors and targeted therapies, mortality rates remain high, underscoring the urgent need for more effective novel approaches. The inherent molecular complexity and heterogeneity of HCC, where only a minority of tumors possess readily targetable drivers, contribute to treatment resistance and More >

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