Special Issues
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Immunotherapy and Chemotherapy: Synergies and Challenges in the Evolving Landscape of Cancer Treatment

Submission Deadline: 30 September 2025 (closed) View: 979 Submit to Journal

Guest Editors

Dr. Walid Shalata

Email: walid.shalata@gmail.com

Affiliation: The Legacy Heritage Cancer Center and Larry Norton Institute, Soroka Medical Center, Beer Sheva 84105, Israel.

Homepage:

Research Interests: Neoplasms, Lung Cancer, Immunotherapy, Chemotherapy

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Summary

Immunotherapy and chemotherapy are two of the most widely used and fundamental treatment modalities in oncology. Immunotherapy leverages the body's immune system to recognize and attack cancer cells, while chemotherapy uses cytotoxic drugs to target rapidly dividing cells, including cancer cells. This special issue delves into the intersection of these two approaches, exploring both their complementary and contrasting roles in the dynamic field of cancer treatment. It offers a comprehensive review of the current state of these therapies, focusing on their underlying mechanisms, potential for synergy, and the promise of more personalized and effective treatment strategies. While challenges such as toxicity and resistance continue to hinder progress, the articles, reviews, and case studies presented in this issue provide valuable insights into how the integration of immunotherapy and chemotherapy can shape the future of cancer treatment. Together, these therapies bring renewed hope for improving patient outcomes through more tailored and innovative approaches.


Keywords

Cancer Immunotherapy, Chemotherapy Resistance, Combination Therapies, Synergistic Treatment Strategies, Personalized Cancer Treatment, Tumor Microenvironment

Published Papers


  • Open Access

    REVIEW

    Combining Chemotherapeutic Agents, Targeted Therapies, Vaccines and Natural Bioactive Compounds for Mesothelioma: Advances and Perspectives

    Raffaele Carrano, Carlotta Zucca, Nicla Cristina, Martina Grande, Eleonora Leti Maggio, Riccardo Bei, Antonio Infante, Chiara Focaccetti, Valeria Lucarini, Loredana Cifaldi, Laura Masuelli, Luciano Mutti, Camilla Palumbo, Monica Benvenuto, Roberto Bei
    Oncology Research, Vol.33, No.9, pp. 2181-2204, 2025, DOI:10.32604/or.2025.066708
    (This article belongs to the Special Issue: Immunotherapy and Chemotherapy: Synergies and Challenges in the Evolving Landscape of Cancer Treatment)
    Abstract Mesothelioma is a rare and aggressive cancer with a poor prognosis and limited therapeutic options. Despite recent advances, conventional treatment approaches remain largely ineffective due to late diagnosis, chemoresistance and immunosuppressive tumor microenvironment. This review reports the latest studies on combination therapies for mesothelioma, focusing on the potential of integrating chemotherapeutic agents, molecularly targeted agents, vaccines and natural bioactive compounds such as polyphenols. Clinical and preclinical studies demonstrate that integrating immune-modulating drugs or molecular inhibitors with chemotherapy can improve survival and reduce tumor progression in mesothelioma models and patients. Vaccine-based strategies show potential for inducing More >

    Graphic Abstract

    Combining Chemotherapeutic Agents, Targeted Therapies, Vaccines and Natural Bioactive Compounds for Mesothelioma: Advances and Perspectives

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