Guest Editors
Dr. Michał Kiełbik
Email: mkielbik@cbm.pan.pl
Affiliation: Institute of Medical Biology, Polish Academy of Sciences, Lodz, 93-232, Poland.
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Research Interests: ovarian cancer, transcription factors, intracellular signaling pathways, chemoresistance, metastasis
Prof. Magdalena Klink
Email: mklink@cbm.pan.pl
Affiliation: Institute of Medical Biology, Polish Academy of Sciences, Lodz, 93-232, Poland.
Homepage:
Research Interests: ovarian cancer, chemoresistance, metastasis, tumor microenvironment, cancer stem cells
Summary
Ovarian cancer (OC) is a gynecological malignancy characterized by the highest mortality rate among women worldwide. In comparison to other tumor types, our understanding of molecular pathways responsible for controlling OC tumor progression, chemoresistance, and metastasis requires further improvement and explanation.
This special issue aims to create a comprehensive overview of the latest advancements in ovarian cancer research and build a collection that highlights the complex molecular mechanisms responsible for driving the tumor progression and metastasis, with particular focus on genetic mutations, transcription factors, signaling pathways, and epigenetic alterations. A key emphasis will be placed on the tumor microenvironment (TME), which involves exploration of dynamic interactions between cancer cells, immune cells, stromal components, and extracellular matrix in order to elaborate on how these relationships influence tumor behavior and therapy resistance. From a clinical standpoint, this issue will cover emerging diagnostic biomarkers, such as protein signatures, circulating tumor DNA, or microRNAs, which may offer promise for earlier detection and personalized monitoring. Moreover, the discussion will be held on novel treatment strategies and combinational approaches, focusing on overcoming resistance and improving patients' outcomes. In summary, this issue will integrate molecular insights of ovarian cancer cells with clinical applications to enhance early diagnosis, prognostic accuracy, and therapeutic efficacy in ovarian cancer management.
With the launch of this Special Issue, we would like to invite scientists and clinicians to contribute and help us build a solid collection of ovarian cancer studies at all levels. Both research and review articles are welcome.
Keywords
Ovarian cancer, molecular targets, chemoresistance, metastasis, tumor micro environment, anti-cancer therapies
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