Guest Editors
Assoc. Prof. Chia-Jung Li
Email: nigel6761@gmail.com
Affiliation: Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
Homepage:
Research Interests: mitochondrial medicine, cancer biology, bioinformatics, aging, precision medicine
Summary
Precision oncology has transformed cancer care by matching actionable molecular alterations to targeted therapies. However, durable responses remain limited because the tumor microenvironment (TME) governs drug penetration, metabolic and signaling plasticity, immune evasion, and both intrinsic and acquired resistance. This Special Issue, "Precision Oncology: Targeted Therapies and Tumor Microenvironment," will highlight integrative advances that connect tumor genomics with spatial, cellular, and functional profiling of the TME to enable rational, biomarker-guided interventions. We welcome original research, methods, reviews, and perspectives across solid and hematologic malignancies. Topics of interest include predictive and pharmacogenomic biomarkers; spatial transcriptomics and single-cell multi-omics; liquid biopsy and longitudinal monitoring; patient-derived models and organoids; mechanisms of resistance and lineage switching; stromal, vascular, and immune crosstalk; microbiome and metabolite influences; and TME-aware combinations (e.g., targeted therapy plus immunotherapy, antibody–drug conjugates, radiopharmaceuticals, nanomedicine, or stromal normalization). We also encourage submissions on innovative clinical trial designs, companion diagnostics, and real-world evidence that accelerate translation to practice. Contributions that propose standardized datasets, computational frameworks, and clinically deployable decision-support tools are particularly encouraged. Ultimately, this collection will map how microenvironmental states can be measured, modulated, and co-targeted to extend benefit.
Graphic Abstract
Keywords
precision oncology, targeted therapy, tumor microenvironment, immuno-oncology, resistance mechanisms, spatial transcriptomics, single-cell multi-omics, liquid biopsy, pharmacogenomics, biomarker-driven trials, stromal–immune crosstalk, combination therapy
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