Special Issues
Table of Content

The Identification of Novel Therapeutic Targets and Elucidation of Molecular Mechanisms of Tumorigenesis

Submission Deadline: 28 February 2026 (closed) View: 1244 Submit to Journal

Guest Editor(s)

Prof. Cesar Lopez-Camarillo

Email: cesar.lopez@uacm.edu.mx

Affiliation: Posgrado en Ciencias Genómicas, Universidad Autónoma de la Ciudad de México, CDMX 03100, Mexico  

Homepage:

Research Interests: microRNAs, lncRNAs, and proteins deregulated in cancer using diverse omics approaches (genomics, proteomics, expression profiling, etc).

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Ph.D. Eloísa Ibarra Sierra

Email: ibsiel2606@yahoo.com

Affiliation: Departamento de Investigación, Instituto Estatal de Cancerología “Dr. Arturo Beltrán Ortega”, Acapulco, Guerrero, México

Homepage:

Research Interests: Regulation of gene expression by microRNAs and lncRNAs in cancer

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Summary

Cancer continues to be a major global health challenge, and effective treatments remain elusive due to the complex and heterogeneous nature of tumors. Understanding the molecular underpinnings of tumorigenesis is critical for identifying novel therapeutic targets, which may lead to more personalized and effective treatment strategies. This special issue will focus on the latest advances in unraveling the molecular mechanisms driving tumor initiation, progression, and metastasis, as well as the discovery of novel therapeutic targets that hold promise for improving cancer therapy.


We welcome contributions that explore, but are not limited to, the following topics:

Identification of key signaling pathways and molecular drivers of tumorigenesis.

Novel approaches to targeting oncogenes, tumor suppressors, and epigenetic regulators.

Mechanisms of drug resistance and strategies to overcome it.

The role of tumor microenvironment, immune evasion, and inflammation in cancer development.

Innovative therapeutic strategies, including small molecules, biologics, and immunotherapies.

The application of multi-omics approaches (genomics, transcriptomics, proteomics, etc.) to identify therapeutic targets.

Insights from preclinical and clinical studies on novel therapies and biomarkers.


This issue aims to bring together researchers working on the frontier of cancer biology and therapeutics to share their discoveries and insights into how we can effectively combat this devastating disease. By highlighting novel therapeutic targets and mechanisms of action, this special issue seeks to contribute to the development of next-generation cancer treatments.


We encourage original research articles, reviews, and short communications that provide new insights into the molecular mechanisms of cancer and innovative therapeutic approaches.


Keywords

Tumorigenesis, Therapeutic Targets, Molecular Mechanisms, Cancer Signaling Pathways, Drug Resistance

Published Papers


  • Open Access

    ARTICLE

    Metabolism-Targeted Therapy Decreases Proliferation and Migration in CRC-Derived Cells by Modulating Wnt/β-Catenin Signaling Pathway

    Samuel Trujano-Camacho, Verónica García-Castillo, Sergio Juárez-Méndez, Héctor Herrera-Orozco, Eduardo López-Urrutia, Nadia Jacobo-Herrera, Eduardo Pérez-Arteaga, German Calderillo-Ruiz, David Cantú-de León, Mauricio Rodríguez-Dorantes, Jossimar Coronel-Hernández, Carlos Pérez-Plasencia
    Oncology Research, DOI:10.32604/or.2026.073826
    (This article belongs to the Special Issue: The Identification of Novel Therapeutic Targets and Elucidation of Molecular Mechanisms of Tumorigenesis)
    Abstract Background: Colorectal cancer (CRC) is the second most frequent cancer in women and the third most frequent in men. Current therapeutic approaches, including surgery, chemotherapy, and targeted therapy, often exhibit limited specificity and are associated with substantial adverse effects, compromising patient outcomes. Consequently, the medical community constantly pursues more efficient and precisely targeted therapeutic strategies. The aim of the study is to describe the effects of the TT on the Wnt/β-catenin signaling pathway and its role in cell proliferation and migration in an azoxymethane/dextran sulfate sodium (AOM/DSS) mice model and colorectal cancer-derived cell lines. Methods:… More >

  • Open Access

    REVIEW

    RNA Expression Signatures in Glioblastoma: A Systematic Review of Tumour Biology and Therapeutic Targets

    Amber Hassan, Badr Hafiz, Taghreed Alsinani, Rakan Bokhari, Dahlia Mirdad, Awab Tayyib, Alaa Alkhotani, Ahmad Fallata, Iman Mirza, Eyad Faizo, Saleh Baeesa, Huda Alghefari, Maher Kurdi
    Oncology Research, Vol.33, No.11, pp. 3293-3325, 2025, DOI:10.32604/or.2025.070031
    (This article belongs to the Special Issue: The Identification of Novel Therapeutic Targets and Elucidation of Molecular Mechanisms of Tumorigenesis)
    Abstract Background: Glioblastoma (GBM) remains the most aggressive primary brain tumour in adults, marked by pronounced cellular heterogeneity, diffuse infiltration, and resistance to conventional treatment. In recent years, transcriptomic profiling has provided valuable insights into the molecular mechanisms that govern the progression of glioblastoma. This systematic review aims to synthesise the current literature on dysregulated gene expression in GBM, focusing on gene signatures associated with stemness, immune modulation, extracellular matrix remodelling, metabolic adaptation, and therapeutic resistance. Methods: We conducted a systematic search of PubMed, The Cancer Genome Atlas (TCGA), Chinese Glioma Genome Atlas (CGGA), and the GlioVis… More >

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